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AP2 gamma AntibodyRabbit Monoclonal Antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AJ1045b | 100ul 400 ul | 2-3 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
AP2 gamma Antibody - Product info | |
| Application | WB, IHC
|
| Primary Accession | Q92754 |
| Reactivity | Human |
| Clone Names | EP2692Y |
| Calculated MW | 49177 Da |
| Gene ID 7022 | |
| Other Names TFAP2C, Transcription factor AP-2 gamma, Activating enhancer-binding protein 2 gamma;Transcription factor ERF-1 | |
| Target/Specificity A synthetic peptide corresponding to residues in human AP2 gamma was used as an immunogen. | |
| Dilution WB~~1:500~1000 IHC~~1:250~500 | |
| Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions AP2 gamma Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
AP2 gamma Antibody - Protein Information | |
| Name TFAP2C | |
| Function Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC | |
| Cellular Location Nucleus (Probable). | |
AP2 gamma Antibody - Application data
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A. Western blot analysis on (A) MCF-7 and (B) SKBR3 cell lysate using anti-AP2-C RabMAb (Cat. #AJ1045b), dilution 1:50,000.
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B. Immunohistochemical analysis of paraffin-embedded human breast carcinoma using anti-AP2C RabMAb. (Cat. #AJ1045b).
AP2 gamma Antibody - Related products
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BACKGROUND
Transcription factor gene AP2-C (AP-2 gamma) belongs to a family of four closely related genes. The AP-2 transcription factor has been shown to play an important role in the development of tissues of ectodermal origin and has also been implicated in mammary oncogenesis (2). A physical and functional association between AP-2gamma transcription factor and the Wwox protein has been demonstrated. results suggest that Wwox tumor suppressor protein inhibits AP-2gamma oncogenic activity by sequestering it in the cytoplasm (2). P-2 gamma had been implicated in multiple functions during proliferation and differentiation based on its expression pattern in trophoblast, neural crest, and ectoderm cells in murine embryos. AP-2 gamma seems to be required in early embryonic development because it regulates the genetic programs controlling proliferation and differentiation of extraembryonic trophectodermal cells (3).
REFERENCES
1. Williamson JA, et al. Genomics 35(1):262-4, 1996
2. Ageilan RI, et al. Cancer Res 64(22): 8256-61, 2004
3. Werling U et al. Mol Cell Biol 22(9):3149-56, 2002
