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Apolipoprotein A-II (ApoA-II) Antibody

Rabbit Monoclonal Antibody

  • WB - Apolipoprotein A-II (ApoA-II) Antibody AJ1051b
    Western blot analysis on human plasma lysates using anti-Apolipoprotein A-II (ApoA-II) RabMAb (Cat. #AJ1051b).
  • IF - Apolipoprotein A-II (ApoA-II) Antibody AJ1051b
    Immunofluorescent staining of HEPG2 cells using anti-ApoAII RabMAb (Cat. #AJ1051b).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P02652
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR2913
Calculated MW 11175 Da
Gene ID 336
Other Names Apolipoprotein A-II, Apo-AII, ApoA-II, Apolipoprotein A2, Proapolipoprotein A-II, ProapoA-II, Truncated apolipoprotein A-II, Apolipoprotein A-II(1-76), APOA2
Target/Specificity A synthetic peptide corresponding to residues in human Apolipoprotein A-II (ApoA-II) was used as an immunogen.
Dilution WB~~1:1000~5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsApolipoprotein A-II (ApoA-II) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name APOA2
Function May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
Cellular Location Secreted.
Tissue Location Plasma; synthesized in the liver and intestine
Research Areas
Citations (0)

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Apolipoprotein A II is the second most abundant protein of the high density lipoprotein particles, accounting for 20% of protein mass of HDL. The concentration of ApoA-I and ApoA-II is inversely correlated with the frequency of heart disease in human (1). In studies with mice and humans, ApoA-II levels have been associated with increased susceptibility to atherosclerosis, increased free fatty acid levels, increased body fat, and increased insulin resistance (2). ApoA-II consists of three potential amphipathic helices of 17 residues each, which contribute to the lipid-binding properties of this apolipoprotein (3). Currently, the best characterized activity of apoA-II is its potent antagonism of the anti-atherogenic and anti-inflammatory activities of ApoA-I, probably due to its competition with the latter for lipid acyl side chains of HDL (1).


1. Kumar et al. Biochemistry. 41 (39):11681-11691, 2002 2. Castellani and Lusis. Arterioscler. Thromb. Vasc. Biol. 21:1870-1872, 2001 3. Benetollo et al. Eur. J. Biochem. 242 :657-664, 1996

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Cat# AJ1051b
(40 western blots)
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