- CITATIONS: 1
|Calculated MW||10852 Da|
|Other Names||Apolipoprotein C-III, Apo-CIII, ApoC-III, Apolipoprotein C3, APOC3|
|Target/Specificity||A synthetic corresponding to C-terminus of human Apolipoprotein CIII was used as immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Apolipoprotein CIII Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors.|
Provided below are standard protocols that you may find useful for product applications.
Apolipoprotein CIII (Apo CIII) is one of 9 known polymorphic forms of apolipoproteins. The apolipoproteins function as stabilizers of intact lipoprotein particles. Specifically, Apo CIII is a very low density lipoprotein (VLDL) protein (1). Apo CIII is involved in inhibition of lipoprotein and hepatic lipases. It is thought to delay catabolism of triglyceride-rich particles. A defect in Apo CIII has been linked to hyperalphalipoproteinemia (HLAP), which causes increased levels of high density lipoprotein (HDL) (2).
1. Hirano, T, et al; Kidney International 63:2171
2. Hirano, K, et al; Arteriosclerosis, Thrombosis, and Vascular Biology, 15:1849-1856, 1995.
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