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Apolipoprotein CIII Antibody

Rabbit Monoclonal Antibody

  • WB - Apolipoprotein CIII Antibody AJ1052a
    A. Western blot analysis on human liver tissue lysates using anti- Apolipoprotein CIII RabMAb (Cat. #AJ1052a), 1:2000 dilution.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P02656
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP1372Y
Calculated MW 10852 Da
Gene ID 345
Other Names Apolipoprotein C-III, Apo-CIII, ApoC-III, Apolipoprotein C3, APOC3
Target/Specificity A synthetic corresponding to C-terminus of human Apolipoprotein CIII was used as immunogen.
Dilution WB~~1:2000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsApolipoprotein CIII Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name APOC3
Function Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors.
Cellular Location Secreted
Tissue Location Liver..
Research Areas
Citations ( 0 )


Apolipoprotein CIII (Apo CIII) is one of 9 known polymorphic forms of apolipoproteins. The apolipoproteins function as stabilizers of intact lipoprotein particles. Specifically, Apo CIII is a very low density lipoprotein (VLDL) protein (1). Apo CIII is involved in inhibition of lipoprotein and hepatic lipases. It is thought to delay catabolism of triglyceride-rich particles. A defect in Apo CIII has been linked to hyperalphalipoproteinemia (HLAP), which causes increased levels of high density lipoprotein (HDL) (2).


1. Hirano, T, et al; Kidney International 63:2171
2. Hirano, K, et al; Arteriosclerosis, Thrombosis, and Vascular Biology, 15:1849-1856, 1995.

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Cat# AJ1052a
(40 western blots)
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