|Application ||WB, IHC|
|Calculated MW||21253 Da|
|Other Names||Apolipoprotein M, Apo-M, ApoM, Protein G3a, APOM, G3A, NG20|
|Target/Specificity||A synthetic peptide corresponding to residues in human Apolipoprotein M was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Apolipoprotein M Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.|
|Cellular Location||Secreted Note=Present in high density lipoprotein (HDL) and to a lesser extent in triglyceride-rich lipoproteins (TGRLP) and low density lipoproteins (LDL)|
|Tissue Location||Plasma protein. Expressed in liver and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
Apolipoprotein M (ApoM) is a novel apolipoprotein mainly present in high-density lipoprotein (HDL) (1,2). It belongs to the lipocalin protein superfamily and may bind a small but so far unknown lipophilic ligand. It is secreted without cleavage of its hydrophobic signal peptide, which probably anchors ApoM in the phospholipid moiety of plasma lipoproteins. Recent studies suggest that ApoM may affect HDL metabolism and have anti-atherogenic functions (2), including possible mechanisms of increased formation of pre-ss HDL, enhanced cholesterol mobilization from foam cells, and increased antioxidant properties (1). In addition to hepatocytes, ApoM is highly expressed in kidney proximal tubule cells (2).
1. Dahlb鋍k B, et al. Cell Mol Life Sci. 66(4):559-64, 2009 2. Christoffersen C, et al. Scand J Clin Lab Invest. 66(7):631-7, 2006
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