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Apolipoprotein-A1 Antibody

Rabbit Monoclonal Antibody

  • WB - Apolipoprotein-A1 Antibody AJ1056a
    A. Western blot analysis on fetal liver lysate using anti-Apo A1 RabMAb (Cat. #AJ1056a).
  • IHC - Apolipoprotein-A1 Antibody AJ1056a
    B. Immunohistochemical staining of paraffin-embedded human liver using anti-Apo-A1RabMAb (Cat. #AJ1056a).
  • IF - Apolipoprotein-A1 Antibody AJ1056a
    C. Immunofluorescent staining of HEPG2 cells using anti-Apo- A1 RabMAb (Cat. #AJ1056a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P02647
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP1368Y
Calculated MW 30778 Da
Gene ID 335
Other Names Apolipoprotein A-I, Apo-AI, ApoA-I, Apolipoprotein A1, Proapolipoprotein A-I, ProapoA-I, Truncated apolipoprotein A-I, Apolipoprotein A-I(1-242), APOA1
Target/Specificity A synthetic peptide corresponding to residues near the N-terminus of human Apo A1 was used as an immunogen.
Dilution WB~~1:500
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsApolipoprotein-A1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name APOA1
Function Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
Cellular Location Secreted.
Tissue Location Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease.
Research Areas
Citations (0)

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Apolipoprotein A1 (apo A1) is the major polypeptide of the human plasma high density lipoprotein (HDL). The structure and function of the apo A1 gene are of interest because of the inverse correlation shown between HDL levels and coronary heart disease (1). The 267 amino acid precursor initially undergoes intracellular co-translational proteolytic cleavage into proapoA-I. ProapoA-I is secreted from the cell and was isolated from thoracic duct lymph in the apoA-I1 isoform position. Results indicate that apo A1 is present in human plasma, and undergoes post-translational proteolytic cleavage to mature plasma apoA-I (2). Cleavage of this protein with cyanogen bromide yields four fragments designated in the order of elution from Bio-Gel P-30 as CNBr I, II, III, and IV (3).


1. Shoulders CC, et al. Nucleic Acids Res. 11(9):2827-37 1983.
2. Brewer HB, et al. Biochem Biophys Res Commun 113(2):626-32, 1983.
3. Baker HN, et al. J Biol Chem 250(7):2725-38, 1975.

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Cat# AJ1056a
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