|Calculated MW||35399 Da|
|Other Names||Apolipoprotein F, Apo-F, Lipid transfer inhibitor protein, LTIP, APOF|
|Target/Specificity||A synthetic peptide corresponding to residues in human Apolipoprotein F (apo F) was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Apolipoprotein-F (ApoF) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII.|
|Tissue Location||Expressed by the liver and secreted in plasma.|
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Provided below are standard protocols that you may find useful for product applications.
Apolipoprotein F (Apo F), also known as lipid transfer inhibitor protein (LTIP) based on its ability to inhibit lipid transfer between lipoproteins, is a protein component of several lipoprotein classes and a physiologic regulator of cholesteryl ester transfer protein (CETP) function (1, 2). Apo F activity was reported to be localized to LDL, consistent with its greater inhibitory activity on this lipoprotein. Apo F activity is controlled by its reversible incorporation into an inactive complex which provides for short-term fine-tuning of lipoprotein remodeling mediated by CETP (1). ApoF overexpression reduces HDL cholesterol levels by increasing clearance of HDL-CE. ApoF may be an important determinant of HDL metabolism and reverse cholesterol transport (2).
1. He Y, et al. J Lipid Res. 49(7):1529-37, 2008
2. Lagor WR, et al. Arterioscler Thromb Vasc Biol. 29(1):40-6, 2008
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