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Aquaporin-5 Antibody

Rabbit Monoclonal Antibody

  • WB - Aquaporin-5 Antibody AJ1059a
    Western blot analysis on (A) fetal lung and (B) SW480 cell lysates using anti-Aquaporin 5 RabMAb (Cat. #AJ1059a).
  • IHC - Aquaporin-5 Antibody AJ1059a
    Immunohistochemical analysis of paraffin-embedded human lung tissue using anti-Aquaporin 5 RabMAb (Cat. #AJ1059a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P55064
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR3747
Calculated MW 28292 Da
Gene ID 362
Other Names Aquaporin-5, AQP-5, AQP5
Target/Specificity A synthetic peptide corresponding to residues in human Aquaporin 5 was used as an immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAquaporin-5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AQP5
Function Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions.
Cellular Location Membrane; Multi-pass membrane protein.
Research Areas
Citations (0)

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Aquaporin 5 is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions (1). It is expressed in epithelia of lung, cornea, and various secretory glands; sites where extracellular osmolality is known to fluctuate (2). Expression of Aquaporin 5 may have pathophysiological implications attributed to a dysfunctional water regulation by Aquaporin 5such as endolymphatic hydrops (i.e. in Meniere's disease) or sensorineural hearing loss (i.e. in Sj鰃ren's syndrome) (3). Up-regulation of Aquaporin 5 may be involved in differentiation of human gastric cancer cells (4).


1. Da Silva N., et al. Biol Reprod. 74(2):427-38, 2006 2. NCBI Reference Sequence (RefSeq): a curated non- redundant sequence database of genomes, transcripts and proteins Pruitt KD, Tatusova, T, Maglott DR Nucleic Acids Res 2007 Jan 1;35(Database issue):D61-5 3. Sidhaye VK, et al. Proc Natl Acad Sci U S A. 103(12):4747-52, 2006 4. Hirt B, et al. The subcellular distribution of aquaporin 5 in the cochlea reveals a water shunt at the perilymph- endolymph barrier, Neuroscience, 2009 5. Watanabe T, et al. J Physiol Sci. 59(2):113-22, 2009

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Cat# AJ1059a
(40 western blots)
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