|Application ||WB, IHC|
|Calculated MW||28292 Da|
|Other Names||Aquaporin-5, AQP-5, AQP5|
|Target/Specificity||A synthetic peptide corresponding to residues in human Aquaporin 5 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Aquaporin-5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
Aquaporin 5 is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions (1). It is expressed in epithelia of lung, cornea, and various secretory glands; sites where extracellular osmolality is known to fluctuate (2). Expression of Aquaporin 5 may have pathophysiological implications attributed to a dysfunctional water regulation by Aquaporin 5such as endolymphatic hydrops (i.e. in Meniere's disease) or sensorineural hearing loss (i.e. in Sj鰃ren's syndrome) (3). Up-regulation of Aquaporin 5 may be involved in differentiation of human gastric cancer cells (4).
1. Da Silva N., et al. Biol Reprod. 74(2):427-38, 2006 2. NCBI Reference Sequence (RefSeq): a curated non- redundant sequence database of genomes, transcripts and proteins Pruitt KD, Tatusova, T, Maglott DR Nucleic Acids Res 2007 Jan 1;35(Database issue):D61-5 3. Sidhaye VK, et al. Proc Natl Acad Sci U S A. 103(12):4747-52, 2006 4. Hirt B, et al. The subcellular distribution of aquaporin 5 in the cochlea reveals a water shunt at the perilymph- endolymph barrier, Neuroscience, 2009 5. Watanabe T, et al. J Physiol Sci. 59(2):113-22, 2009
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