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B7-H4 AntibodyRabbit Monoclonal Antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AJ1073a | 100ul 400 ul | 2-3 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
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B7-H4 Antibody - Product info | |
| Application | WB, IHC
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| Primary Accession | Q7Z7D3 |
| Reactivity | Human, Mouse, Rat |
| Clone Names | EP1165 |
| Calculated MW | 30878 Da |
| Gene ID 79679 | |
| Target/Specificity A peptide corresponding to residues near N-term of human GNB2 was used as an immunogen. | |
| Dilution WB~~1:500 IHC~~1:250~500 | |
| Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions B7-H4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
B7-H4 Antibody - Protein Information | |
| Name VTCN1 | |
| Synonyms B7H4 | |
| Function Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor- associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation | |
| Cellular Location Cell membrane; Single-pass type I membrane protein (Potential). Note=Expressed at the cell surface. A soluble form has also been detected | |
| Tissue Location Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC) Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis | |
B7-H4 Antibody - Related products
AP9802c: VTCN1 Antibody (Center)
B7-H4 Antibody - Application data
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Western blot analysis on A) fetal spleen B) fetal thymus, C) SKBR-3 lysates using anti-B7-H4 RabMAb (Cat. #AJ1073a), 1:10,000 dilution.
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Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-B7-H4 RabMAb (Cat. #AJ1073a)
B7-H4 Antibody - Research Areas
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BACKGROUND
As a member of B7 family, B7-H4 (VTCN1) plays a critical role in the regulation of antigen-specific immune responses. B7-H4 is a co-stimulatory protein expressed in activated T cells and is involved in the negative regulation of cell-mediated immunity in peripheral tissues (1). B7-H4 ligation to its receptor BTLA T-lymphocytes results in inhibition of T-cell activation, cytokine secretion, and the development of cytotoxicity (2). B7-H4 protein is typically expressed on the surface of activated T-cells, B-cells, monocytes, and dendritic cells, but not in most normal tissues. In tissues, B7-H4 is over expressed in breast, endometrial, ovarian, renal cell (RCC), and non-small cell lung carcinomas (NSCLC). B7-H4 has been identified as an important cancer marker for breast and ovarian cancers (3).
REFERENCES
1. Tringler B, et al.,Clinical Cancer Research 11:1842-1848, 2005. 2. The UniProt Consortium, The Universal Protein Resource (UniProt), Nucleic Acids Res. 36:D190-D195(2008). 3. Simon I, et al., Cancer Research 66:1570 - 1575, 2006.
