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Bad Antibody (N-term)

Rabbit Monoclonal Antibody

  • WB - Bad Antibody (N-term) AJ1074a
    A.Western blot analysis on Hela cell lysate using anti-Bad (N-term) RabMAb (Cat. #AJ1074a), dilution 1:5,000.
  • IHC - Bad Antibody (N-term) AJ1074a
    B. Immunohistochemical staining of paraffin-embedded human lymphoma using anti-Bad (N-term) RabMAb (Cat. #AJ1074a)
  • IHC - Bad Antibody (N-term) AJ1074a
    C. Immunohistochemical staining of paraffin-embedded human lymphoma using a anti-Bad (N-term) RabMAb (Cat. #AJ1074a)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92934
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names Y208
Calculated MW 18392 Da
Gene ID 572
Other Names Bcl2-associated agonist of cell death, BAD, Bcl-2-binding component 6, Bcl-2-like protein 8, Bcl2-L-8, Bcl-xL/Bcl-2-associated death promoter, Bcl2 antagonist of cell death, BAD, BBC6, BCL2L8
Target/Specificity A synthetic peptide corresponding to residues in the N-term of human Bad was used as immunogen. The antibody does not cross-react with other Bcl-2 members.
Dilution WB~~1:10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBad Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BAD
Synonyms BBC6, BCL2L8
Function Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
Cellular Location Mitochondrion outer membrane. Cytoplasm {ECO:0000250|UniProtKB:Q61337}. Note=Colocalizes with HIF3A in the cytoplasm (By similarity). Upon phosphorylation, locates to the cytoplasm. {ECO:0000250|UniProtKB:Q61337}
Tissue Location Expressed in a wide variety of tissues.
Research Areas
Citations (0)

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Bad is a pro-apoptotic member of the Bcl-2 family. Bad will bind preferentially Bcl-xL over Bcl-2 through its partial (9-16 a.a) BH3 domain. Additionally, Bad can reverse the death repressor activity of Bcl-xL but not of Bcl-2. Upon dephosphorylation, activated Bad translocates to the mitochondria and displace Bcl-2 from tBid sequestration to initiate mitochondrial dysfunction. The switching on/off of its phosphorylation by growth/survival factors regulates Bad activity.


1. Greider, C.W., and Blackburn, E.H. (1985). Cell 43, 405-413
2. Feng J, Funk WD, Wang SS, et al. Science 1995; 269:1236-41
3. Greider, C.W. (1996). Telomere length regulation. Annu. Rev. Biochem. 65, 337-365
4. Shay JW, Cacchetti SA, Eur J Cancer. 1997:33:787-791

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Cat# AJ1074a
(40 western blots)
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