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Bag-2 Antibody

Rabbit Monoclonal Antibody

     
  • WB - Bag-2 Antibody AJ1076a
    A. Western blot analysis on (A) Jurkat (B) HeLa and (C) HepG2 cell lysate using anti-Bag2 RabMAb (Cat. #AJ1076a), dilution 1:5000.
  • IHC - Bag-2 Antibody AJ1076a
    B. Immunohistochemical analysis of paraffin-embedded human ovarian carcinoma tissue using anti-BAG2 RabMAb (Cat. #AJ1076a).
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession O95816
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR3567
Calculated MW 23772 Da
Gene ID 9532
Other Names BAG family molecular chaperone regulator 2, BAG-2, Bcl-2-associated athanogene 2, BAG2
Target/Specificity A synthetic peptide corresponding to residues in the N-terminus of human Bag-2 was used as immunogen.
Dilution WB~~1:20000~200000
IHC~~1:100
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBag-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BAG2
Function Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release.
Research Areas
Citations (0)

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Background

BAG-2 is a member of a family of BAG-related proteins (BAG-2, BAG-3, BAG-4, BAG-5). BAG-family proteins may play a role in providing opportunities for specification and diversification of Heat Shock Protein (Hsp70) chaperone functions. Hsp70 family molecular chaperones play critical roles in protein folding and trafficking in all eukaryotic cells. BAG-1 binds the ATPase domains of Hsp70 and Hsc70, modulating their chaperone activity and functioning as a competitive antagonist of the co-chaperone Hip. BAG-2 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner (1).

References

1. Takayama S, et al. J Biol Chem. 274(2):781-6, 1999

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Discontinued
Cat# AJ1076a
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