|Application ||WB, IF|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||23772 Da|
|Other Names||BAG family molecular chaperone regulator 2, BAG-2, Bcl-2-associated athanogene 2, BAG2|
|Target/Specificity||A synthetic peptide corresponding to residues in the C-terminus of human Bag-2 was used as immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Bag-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release (PubMed:24318877, PubMed:9873016).|
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Provided below are standard protocols that you may find useful for product applications.
BAG-2 is a member of a family of BAG-related proteins (BAG-2, BAG-3, BAG-4, BAG-5). BAG-family proteins may play a role in providing opportunities for specification and diversification of Heat Shock Protein (Hsp70) chaperone functions. Hsp70 family molecular chaperones play critical roles in protein folding and trafficking in all eukaryotic cells. BAG-1 binds the ATPase domains of Hsp70 and Hsc70, modulating their chaperone activity and functioning as a competitive antagonist of the co-chaperone Hip. BAG-2 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner (1).
1. Takayama S, et al. J Biol Chem. 274(2):781-6, 1999
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