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YWHAE Antibody

Rabbit Monoclonal IgG

Produced using Abcam's RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487
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Ordering Information
Catalog # SizeAvailability Price  
AJ1077a 100µl 2-3 days $ 295.00 Add to cart
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YWHAE Antibody - Product Information

  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • ICC=Immunocytochemistry
  • CHIP=Chromatin Immunoprecipitation
  • IHCF=Immunohistochemistry (Frozen Sections)
  • FA=Fluorescence Assay
  • IHCP=Immunohistochemistry (Paraffin-embedded Sections)
  • IC=Immunochemistry
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary AccessionO95817
Clone NamesEPR3515
Calculated MW61595 Da
Gene ID 9531
Other Names
BAG family molecular chaperone regulator 3, BAG-3, Bcl-2-associated athanogene 3, Bcl-2-binding protein Bis, Docking protein CAIR-1, BAG3, BIS
A synthetic peptide corresponding to residues in human Bag-3 was used as an immunogen.
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
YWHAE Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

YWHAE Antibody - Protein Information

Name BAG3
Synonyms BIS
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity.

YWHAE Antibody - Research Areas

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Provided below are standard protocols that you may find useful for product applications.


Bcl-2-associated athanogene 3 (Bag-3) is a member of a conserved family of cyto-protective proteins that bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone acitivity in a Hip-repressible manner. It has been shown to be prominently expressed in striated muscle and colocalizes with Z-disks. Bag-3 is not required for muscle development, but appears to be critically important for maintenance of mature skeletal muscle (1-2). Bag-3 has also been shown to have anti-apoptotic activity (3). Overexpression of Bag-3 has prevented or reduced the distraction of polyubiquitinated Hsp90/Hsp70 client proteins such as Cyclin D1, Akt, glycogen synthase 3B, and p70s6 kinase, and facilitated cell survival (4).


1. Homma S, et al. Am J Pathol. 169(3):761-73, 2006 2. NCBI Reference Sequence (RefSeq): a curated non- redundant sequence database of genomes, transcripts and proteins Pruitt KD, Tatusova, T, Maglott DR Nucleic Acids Res 2007 Jan 1;35(Database issue):D61-5 3. The UniProt Consortium. The Universal Protein Resource (UniProt). Nucleic Acids Res. 36:D190-D195 (2008) 4. Virador VM., et al. PLoS One 4(4):e5136, 2009