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YWHAE AntibodyRabbit Monoclonal IgG
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AJ1077a | 100ul 400 ul | 2-3 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
YWHAE Antibody - Product info | |
| Application | WB
|
| Primary Accession | O95817 |
| Reactivity | Human |
| Clone Names | EPR3515 |
| Calculated MW | 61595 Da |
| Gene ID 9531 | |
| Target/Specificity A synthetic peptide corresponding to residues in human Bag-3 was used as an immunogen. | |
| Dilution WB~~1:1000~10000 | |
| Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions YWHAE Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
YWHAE Antibody - Protein Information | |
| Name BAG3 | |
| Synonyms BIS | |
| Function Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity | |
YWHAE Antibody - Application data
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Western blot analysis on (A) 293T, (B) HeLa, (C) MCF-7 and (D) K562 cell lysates using anti-Bag-3 RabMAb (Cat. #AJ1077a).
YWHAE Antibody - Related products
AP10671b: YWHAE Antibody (C-term)
AP3000a: Phospho-YWHAE-pS58 Antibody
AP3001a: Phospho-YWHAE-pT232 Antibody
AP5837a: YWHAE Antibody (N-term)
RI15774: YWHAE predesign siRNA
BP3000a: Phospho-14-3-3-S58 Antibody Blocking Peptide
BP3001a: Phospho-14-3-3-T232 Antibody Blocking Peptide
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Bcl-2-associated athanogene 3 (Bag-3) is a member of a conserved family of cyto-protective proteins that bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone acitivity in a Hip-repressible manner. It has been shown to be prominently expressed in striated muscle and colocalizes with Z-disks. Bag-3 is not required for muscle development, but appears to be critically important for maintenance of mature skeletal muscle (1-2). Bag-3 has also been shown to have anti-apoptotic activity (3). Overexpression of Bag-3 has prevented or reduced the distraction of polyubiquitinated Hsp90/Hsp70 client proteins such as Cyclin D1, Akt, glycogen synthase 3B, and p70s6 kinase, and facilitated cell survival (4).
REFERENCES
1. Homma S, et al. Am J Pathol. 169(3):761-73, 2006 2. NCBI Reference Sequence (RefSeq): a curated non- redundant sequence database of genomes, transcripts and proteins Pruitt KD, Tatusova, T, Maglott DR Nucleic Acids Res 2007 Jan 1;35(Database issue):D61-5 3. The UniProt Consortium. The Universal Protein Resource (UniProt). Nucleic Acids Res. 36:D190-D195 (2008) 4. Virador VM., et al. PLoS One 4(4):e5136, 2009
