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Bak Antibody

Rabbit Monoclonal Antibody

  • WB - Bak Antibody AJ1078a
    A. Western blot analysis on Hela cell lysate using anti-Bak RabMAb (Cat. #AJ1078a). dilution 1:5,000.
  • IHC - Bak Antibody AJ1078a
    B. Immunohistochemical analysis of paraffin-embedded human stomack carcinoma using anti-Bak RabMAb (Cat. #AJ1078a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q16611
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names Y164
Calculated MW 23409 Da
Gene ID 578
Other Names Bcl-2 homologous antagonist/killer, Apoptosis regulator BAK, Bcl-2-like protein 7, Bcl2-L-7, BAK1, BAK, BCL2L7, CDN1
Target/Specificity A synthetic peptide corresponding to residues near the N-term of human Bak was used as immunogen. The antibody does not cross-react with other Bcl-2 members.
Dilution WB~~1:5000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBak Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BAK1
Synonyms BAK, BCL2L7, CDN1
Function In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti- apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.
Cellular Location Mitochondrion membrane; Single-pass membrane protein
Tissue Location Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle
Research Areas
Citations (0)

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Bak a pro-apoptotic analog to Bax, is a member of the Bcl-2 family of proteins. During mitochondria-regulated programmed cell death, Bak promotes apoptosis by binding Bcl-2 and inhibiting its anti-apoptotic function (1). Upon apoptotic stimulation, Bak translocates from the cytosol to the mitochondrial membrane (2). Pro-apoptotic cascade activates BID, which oligomerizes Bak into pores that result in the release of cytochrome c (2, 3). In healthy cells, Bak associate with Bcl-xL and Mcl-1 but not with Bcl-2, Bcl-w or A1 and only when freed of both Bak will induce apoptosis.


1. Greider, C.W., and Blackburn, E.H. (1985). Cell 43, 405-413.
2. Feng J, Funk WD, Wang SS, et al. Science 1995; 269:1236-41.
3. Greider, C.W. (1996). Telomere length regulation. Annu. Rev. Biochem. 65, 337-365.

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Cat# AJ1078a
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