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Bcl-10 Antibody (C-term)

Rabbit Monoclonal Antibody

  • WB - Bcl-10 Antibody (C-term) AJ1080b
    A. Western blot analysis on Raji cell lysate using anti-Bcl-10 (C-term) RabMAb (Cat. #AJ1080b), dilution 1:5,000.
  • IHC - Bcl-10 Antibody (C-term) AJ1080b
    B. Immunohistochemical analysis of paraffin-embedded human hepatocellular carcinoma using anti-BCL-10 (C-term) RabMAb (Cat. #AJ1080b).
  • IF - Bcl-10 Antibody (C-term) AJ1080b
    C. Immunofluorescent staining of HeLa cells using anti-BCL-10 (C-term) RabMAb (Cat. #AJ1080b).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95999
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP606Y
Calculated MW 26252 Da
Gene ID 8915
Other Names B-cell lymphoma/leukemia 10, B-cell CLL/lymphoma 10, Bcl-10, CARD-containing molecule enhancing NF-kappa-B, CARD-like apoptotic protein, hCLAP, CED-3/ICH-1 prodomain homologous E10-like regulator, CIPER, Cellular homolog of vCARMEN, cCARMEN, Cellular-E10, c-E10, Mammalian CARD-containing adapter molecule E10, mE10, BCL10, CIPER, CLAP
Target/Specificity A synthetic peptide corresponding to residues in the C-term of human Bcl-10 was used as immunogen.
Dilution WB~~1:5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBcl-10 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BCL10
Synonyms CIPER, CLAP
Function Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF- kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101).
Cellular Location Cytoplasm, perinuclear region. Membrane raft. Note=Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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Bcl-10 is an adaptor protein with a caspase recruitment domain (CARD) that promotes apoptosis and activates pro-caspase 9 and NF-kB (1-2). Bcl-10 also interacts with other CARD domain containing proteins including CARD9, 10, 11 and 14. Bcl-10 is found to form a complex with MALT1, a protein known to be translocated in MALT lymphomas. Bcl-10 and MALT1 play a critical role in antigen receptormediated lymphocyte proliferation and signaling to NF-B, which controls the expression of genes critical for cell survival, proliferation, and immune responses (3-4). Defects in Bcl-10 have been identified in various types of cancer.


1. Wotherspoon, A. C.; Pan, L. X.; Diss, T. C.; Isaacson, P. G. : Cancer Genet. Cytogenet. 58: 35-38, 1992
2. Zhang, Q. et al. 1999.Nat. Genet. 22:63-68
3. Ruland, J. et al. 2001. Cell. 104:33-42.
4. Ruefli-Brasse et al. Science. 302:1581-1584

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Cat# AJ1080b
(40 western blots)
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