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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   Bcl-2 A1/Bfl1 Antibody (N-term)   

Bcl-2 A1/Bfl1 Antibody (N-term)

Rabbit Monoclonal Antibody

  • WB - Bcl-2 A1/Bfl1 Antibody (N-term) AJ1081a
    A. Western blot analysis on Raji cell lysate using anti- Bcl-2-related protein A1 (N-term) RabMAb (Cat. #AJ1081a), dilution 1:500.
  • IHC - Bcl-2 A1/Bfl1 Antibody (N-term) AJ1081a
    B. Immunohistochemical analysis of paraffin-embedded human adenocarcinoma using anti-Bcl-2-related protein A1 (N-term)RabMAb (Cat. #AJ1081a).
  • IF - Bcl-2 A1/Bfl1 Antibody (N-term) AJ1081a
    C. Immunofluorescent staining of HeLa cells using anti-Bcl-2-related protein A1 (N-term) RabMAb (Cat. #AJ1081a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q16548
Reactivity Human, Mouse
Host Rabbit
Clonality Monoclonal
Clone Names EP517Y
Calculated MW 20132 Da
Gene ID 597
Other Names Bcl-2-related protein A1, Bcl-2-like protein 5, Bcl2-L-5, Hemopoietic-specific early response protein, Protein BFL-1, Protein GRS, BCL2A1, BCL2L5, BFL1, GRS, HBPA1
Target/Specificity A synthetic peptide corresponding to residues in the N-term of human Bcl-2 related protein A1 was used as immunogen.
Dilution WB~~1:5000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBcl-2 A1/Bfl1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BCL2A1
Synonyms BCL2L5, BFL1, GRS, HBPA1
Function Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity).
Cellular Location Cytoplasm.
Tissue Location Seems to be restricted to the hematopoietic compartment. Expressed in peripheral blood, spleen, and bone marrow, at moderate levels in lung, small intestine and testis, at a minimal levels in other tissues. Also found in vascular smooth muscle cells and hematopoietic malignancies
Research Areas
Citations (0)

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Bcl-2 related protein A1; also known as Bcl2A1 and Bfl1, is an anti-apoptotic Bcl-2 family member preferentially expressed in hematopoietic and endothelial cells (1). Bfl1 is involved in a variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. Expression of Bfl1 is stimulated by NF-kB in response to inflammatory stimuli and up-regulated by TNF-alpha, IL1-beta, IGF1, GMC-SF, CD40 and phorbol ester (2-3). Bfl1 has also been shown to reduce the release of pro-apoptotic cytochrome c from mitochondria, block caspase activation and suppress apoptosis induced by p53 (4-5).


1. Lin, E. Y.; Orlofsky, A.; Berger, M. S.; Prystowsky, M. B.: J. Immun. 151: 1979-1988, 1993.
2. Lee, H. H., Dadgostar, H., Cheng, Q., Shu, J., and Cheng, G. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 9136-9141
3. Zong, W.-X., Edelstein, L. C., Chen, C., Bash, J., and Gelinas, C. (1999) Genes Dev. 13, 382-387
4. D'Sa-Eipper, C.; Subramanian, T.; Chinnadurai, G. : Cancer Res. 56: 3879-3882, 1996.
5. Arlette B. Werner, Evert de Vries, Stephen W. G. Tait, Ilja Bontjer, and Jannie Borst; J. Biol. Chem., Vol. 277, Issue 25, 22781-22788, June 21, 2002

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Cat# AJ1081a
(40 western blots)
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