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Bcl-6 Antibody (C-term)Rabbit Monoclonal Antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AJ1083a | 100ul 400 ul | 2-3 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
Bcl-6 Antibody (C-term) - Product info | |
| Application | WB, IHC
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| Primary Accession | P41182 |
| Reactivity | Human |
| Clone Names | EP529Y |
| Calculated MW | 78846 Da |
| Gene ID 604 | |
| Other Names BCL6, BCL5, LAZ3, ZBTB27, ZNF51, B-cell lymphoma 6 protein, Zinc finger protein 51;LAZ-3 protein;BCL-5;Zinc finger and BTB domain-containing protein 27 | |
| Target/Specificity A synthetic peptide corresponding to residues in the C-term of human Bcl-6 was used as immunogen. | |
| Dilution IHC~~1:50~100 | |
| Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions Bcl-6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
Bcl-6 Antibody (C-term) - Protein Information | |
| Name BCL6 | |
| Synonyms BCL5, LAZ3, ZBTB27, ZNF51 | |
| Function Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis | |
| Cellular Location Nucleus (By similarity). | |
| Tissue Location Expressed in germinal center T and B-cells and in primary immature dendritic cells | |
Bcl-6 Antibody (C-term) - Related products
AP13061b: BCL6 Antibody (C-term)
AP7372b: Bcl-6 Antibody (C-term)
Bcl-6 Antibody (C-term) - Application data
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A. Western blot analysis on Daudi cell lysate using anti-Bcl-6 (C-term) RabMAb (Cat. #AJ1083a), dilution 1:2,000.
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B. Immunohistochemical analysis of paraffin-embedded human lung adenocarcinoma using anti-Bcl-6 (C-term) RabMAb (Cat. #AJ1083a).
Bcl-6 Antibody (C-term) - Research Areas
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BACKGROUND
Bcl-6 (also known as LAZ3) is a member of the POZ/zinc finger (POK) family that contains an N-terminal POZ domain and 6 C-terminal zinc finger motifs (1). Bcl-6 is a transcriptional regulator that plays an important role in lymphocyte, myocyte, male germ cells, and keratinocyte survival and or differentiation (2-3). Bcl-6 has also been found to repress a number of genes involved in B cell activation and terminal differentiation, inflammation and cell cycle regulation (4). Chromosomal aberration in Bcl-6 may be a cause of B-cell non Hodgkin lymphoma and B-cell leukemia (5).
REFERENCES
1. Kerckaert, J.-P., Deweindt, C., Tilly, H., Quief, S., Lecocq, G., and Bastard, C. (1993) Nat. Genet. 5, 66-70
2. Dent, A. L., Shaffer, A. L., Yu, X., Allman, D., and Staudt, L. M. (1997) Science 276, 589-592
3. Kumagai, T., Miki, T., Kikuchi, M., Fukuda, T., Miyasaka, N., Kamiyama, R., and Hirosawa, S. (1999) Oncogene 18, 467-475
4. Shaeffer, A. L., Yu, X., He, Y., Boldrick, J., Chan, E. P., and Staudt, L. M. (2000) Immunity 13, 199-212
5. Baron, B. W.; Nucifora, G.; McCabe, N.; Espinosa, R., III; Le Beau, M. M.; McKeithan, T. W. : Proc. Nat. Acad. Sci. 90: 5262-5266, 1993.
