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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Beta-2-Microglobulin Antibody   

Beta-2-Microglobulin Antibody

Rabbit Monoclonal Antibody

     
  • WB - Beta-2-Microglobulin Antibody AJ1088a
    A. Western blot analysis on (A) Raji, (B) U937, (C) HeLa and (D) human bone marrow lysates using anti-beta-2-microglobulin RabMAb (Cat. #AJ1088a), dilution 1:200,000.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P61769
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP2978Y
Calculated MW 13715 Da
Gene ID 567
Other Names Beta-2-microglobulin, Beta-2-microglobulin form pI 53, B2M
Target/Specificity A synthetic peptide corresponding to residues on the C-terminus of human beta-2-microglobulin was used as an immunogen.
Dilution WB~~1:1000~5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBeta-2-Microglobulin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name B2M
Function Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553).
Cellular Location Secreted. Cell surface. Note=Detected in serum and urine (PubMed:1336137, PubMed:7554280). {ECO:0000269|PubMed:7554280, ECO:0000269|Ref.6}
Research Areas
Citations (0)

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Background

Beta-2-microglobulin (B2M) is a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells (1). It is a major component forming amyloid deposits in patients with hemodialysis-associated amyloidosis (HAA), a serious complication of long-term hemodialysis (2). B2M is found to contain two antiparallel beta-sheets, each of four beta-strands with the beta-sheets being connected by a single disulfide linkage. No evidence for any regular helical structure is found (3). B2M is an example of a low molecular weight serum protein, with a prominent beta-pleated sheet structure, that may adopt the fibrillar configuration of amyloid in certain pathologic states (4).

References

1. Gussow D, et al J. Immun. 139: 3132-3138, 1987
2. Miyata T, et al Biochemistry 33(40):12215-21, 1994
3. Okon M, et al Biochemistry 31(37):8906-15, 1992
4. Gorevic PD, et al J Clin Invest. 76(6):2425-9, 1985

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Discontinued
Cat# AJ1088a
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