|Reactivity||Human, Mouse, Rat|
|Calculated MW||13715 Da|
|Other Names||Beta-2-microglobulin, Beta-2-microglobulin form pI 53, B2M|
|Target/Specificity||A synthetic peptide corresponding to residues on the C-terminus of human beta-2-microglobulin was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Beta-2-Microglobulin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.|
|Cellular Location||Secreted. Note=Detected in serum and urine|
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Provided below are standard protocols that you may find useful for product applications.
Beta-2-microglobulin (B2M) is a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells (1). It is a major component forming amyloid deposits in patients with hemodialysis-associated amyloidosis (HAA), a serious complication of long-term hemodialysis (2). B2M is found to contain two antiparallel beta-sheets, each of four beta-strands with the beta-sheets being connected by a single disulfide linkage. No evidence for any regular helical structure is found (3). B2M is an example of a low molecular weight serum protein, with a prominent beta-pleated sheet structure, that may adopt the fibrillar configuration of amyloid in certain pathologic states (4).
1. Gussow D, et al J. Immun. 139: 3132-3138, 1987
2. Miyata T, et al Biochemistry 33(40):12215-21, 1994
3. Okon M, et al Biochemistry 31(37):8906-15, 1992
4. Gorevic PD, et al J Clin Invest. 76(6):2425-9, 1985
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