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ADRBK1 Antibody (C-term)

Rabbit Monoclonal Antibody

  • WB - ADRBK1 Antibody (C-term) AJ1090a
    A. Western blot analysis on U937 cell lysate using anti- Beta-ARK1 (GRK2) RabMAb (Cat. #AJ1090a). dilution 1:500.
  • IHC - ADRBK1 Antibody (C-term) AJ1090a
    B. Immunohistochemical analysis of paraffin-embedded human breast carcinoma using anti-Beta-ARK1 (GRK2) RabMAb (Cat. #AJ1090a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P25098
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names Y137
Calculated MW 79574 Da
Gene ID 156
Other Names Beta-adrenergic receptor kinase 1, Beta-ARK-1, G-protein coupled receptor kinase 2, ADRBK1, BARK, BARK1, GRK2
Target/Specificity A synthetic peptide corresponding to residues in the C-terminus of human Beta-ARK1 was used as an immunogen. The antibody does not cross-react with other GPRK family member.
Dilution WB~~1:500~1000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsADRBK1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms BARK, BARK1, GRK2
Function Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:P21146}. Cell membrane {ECO:0000250|UniProtKB:P21146}
Tissue Location Expressed in peripheral blood leukocytes.
Research Areas
Citations (0)

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Beta-Adrenergic receptor kinase (β-ARK1) also known as GRK2 is part of the G Serine /Threonine protein-coupled receptor kinase family (1). β-ARK1 specifically phosphorylates G protein-coupled receptors in their activated form (agonist-bound state). Phosphorylation occurs in the carboxyl terminal tail of the receptor(2). Additionally, phosphorylation of the receptor by β-ARK1 requires β-Arrestin to induce complete homologous desentisization(3).


1. Premont, R. T., Inglese, J., and Lefkowitz, R. J. (1995) FASEB J. 9, 175-182
2. Premont, R., Koch, W. J., Inglese, J., and Lefkowitz, R. J. (1994) Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases. J. Biol. Chem. 269, 6832-6841
3. Lefkowitz, R.J. G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization. J. Biol. Chem. 273: 18677

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Cat# AJ1090a
(40 western blots)
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