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Bim Antibody

Rabbit Monoclonal Antibody

  • WB - Bim Antibody AJ1100a
    A. Western blot analysis on A431 cell lysate using anti-Bim RabMAb (Cat. #AJ1100a).
  • IHC - Bim Antibody AJ1100a
    B. Immunohistochemical analysis of paraffin-embedded breast carcinoma using anti-Bim RabMAb (Cat. #AJ1100a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O43521
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names Y36
Calculated MW 22171 Da
Gene ID 10018
Other Names Bcl-2-like protein 11, Bcl2-L-11, Bcl2-interacting mediator of cell death, BCL2L11, BIM
Target/Specificity A synthetic peptide corresponding to residues in the exons 2 of human Bim was used as immunogen. The antibody can recognize all isoforms of Bim. The antibody does not cross-react with other Bcl-2 family members.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBim Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BCL2L11
Synonyms BIM
Function Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.
Cellular Location Endomembrane system; Peripheral membrane protein. Note=Associated with intracytoplasmic membranes. Isoform BimL: Mitochondrion. Isoform Bim-alpha1: Mitochondrion.
Tissue Location Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are ubiquitously expressed with a tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney
Research Areas
Citations (0)

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Bim, Bcl-2 interacting mediator of cell death, is a pro-apoptotic protein belonging to the BH3-only group of Bcl-2 family members (1). Bim promotes apoptosis by binding to and inhibiting the activity of anti-apoptotic Bcl-2 family members, inducing the release of cytochrome c from mitochondria (2). Bim is sequestered in an inactive conformation through binding to the microtubule-associated dynein motor complex. Certain apoptotic stimuli release Bim from microtubules, allowing inhibitory binding to anti-apoptotic Bcl-2 family members and subsequent iniation of apoptosis (3,4).


1. O'Connor, L., et al. Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBO J. 17: 384?395 (1998).
2. Hsu, S.Y., et al. BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members. Mol. Endocrinol. 12: 1432
3. Puthalakath, H., et al. The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. Mol. Cell 3: 287
4. Strasser, A., et al. The role of Bim, a proapoptotic BH3-only member of the Bcl-2 family in cell-death control. Ann N Y Acad Sci. 917: 541

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Cat# AJ1100a
(40 western blots)
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