|Application ||WB, IHC|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||14954 Da|
|Other Names||Cell cycle exit and neuronal differentiation protein 1, BM88 antigen, CEND1, BM88|
|Target/Specificity||A synthetic peptide corresponding to residues in human BM88 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BM88 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in neuroblastoma cell differentiation.|
|Cellular Location||Membrane; Single-pass type IV membrane protein|
|Tissue Location||Neuron specific.|
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Provided below are standard protocols that you may find useful for product applications.
BM88 is a neuron-specific protein widely distributed in the nervous system and implicated in cell cycle exit and differentiation of neuronal precursors (1, 2). It is an integral membrane protein, which appears early during brain development and remains at high levels at the mature state (1). It is expressed in terminally differentiated neurons and also in neuronal progenitors, in lower levels. BM88 expression shows a tight correlation with the progression of progenitor cells towards neuronal differentiation (2). BM88 is crucial for the transition from neuroblasts to mature neurons when reaching high levels (3).
1. Mamalaki A, et al. J Biol Chem. 270(23):14201-8, 1995 2. Katsimpardi L, et al. Stem Cells. 26(7):1796-807, 2008 3. Papadodima O, et al. J Neurochem. 95(1):146-59, 2005
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