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BNP AntibodyRabbit Monoclonal Antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AJ1105a | 100ul 400 ul | 2-3 days | $ 275.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
BNP Antibody - Product info | |
| Application | WB
|
| Primary Accession | P16860 |
| Reactivity | Human |
| Clone Names | EPR3735 |
| Calculated MW | 14726 Da |
| Gene ID 4879 | |
| Target/Specificity A synthetic peptide corresponding to residues in human BNP was used as an immunogen. | |
| Dilution WB~~1:2000~20000 | |
| Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions BNP Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
BNP Antibody - Protein Information | |
| Name NPPB | |
| Function Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 | |
| Cellular Location Secreted. | |
| Tissue Location Brain and also in atria, but at much lower levels than ANP | |
BNP Antibody - Application data
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Western blot analysis on (A) human plasma and (B) fetal heart lysates using anti-BNP RabMAb (Cat. #AJ1105a).
BNP Antibody - Related products
AP10123b: BCAR1 Antibody (C-term)
AP12200c: p130cas Antibody (Center Y224)
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
B-type natriuretic peptide (BNP) is a cardiac neurohormone specifically secreted from the ventricles in response to volume expansion and pressure overload (1). The actions of BNP include natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. It is also found to help restore the body's salt and water balance and improve heart function (2). BNP is co-secreted along with a biologically inactive N-terminal fragment (NT-proBNP). Circulating BNP and NT-proBNP provide important information on cardiac dysfunction, hypervolemia, and risk in patients with severe impairment of kidney function (3).
REFERENCES
1. Maisel AS, et al. N Engl J Med. 347(3):161-7, 2002 2. The UniProt Consortium. The Universal Protein Resource (UniPrto), Nucleic Acids Res. 36:D190-D195 (2008) 3. Khalifeh N., et al. J Investig Med. 57(1):33-9, 2009
