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C/EBP Beta Antibody (C-term)Rabbit Monoclonal Antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AJ1110a | 100ul 400 ul | 2-3 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
C/EBP Beta Antibody (C-term) - Product info | |
| Application | WB, IF
|
| Primary Accession | P21272 |
| Reactivity | Human, Rat |
| Clone Names | E299 |
| Calculated MW | 31503 Da |
| Gene ID 24253 | |
| Other Names Cebpb, Crp2, Sfb, CCAAT/enhancer-binding protein beta, C/EBP-related protein 2 | |
| Target/Specificity A synthetic peptide corresponding to residues in C-terminus of rat C/EBP b was used as immunogen. The antibody can recognize three C/EBPb isoform (i.e. LAP*, LAP, and LIP). | |
| Dilution WB~~1:500~1000 | |
| Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions C/EBP Beta Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
C/EBP Beta Antibody (C-term) - Protein Information | |
| Name Cebpb | |
| Synonyms Crp2, Sfb | |
| Function Involved in interleukin-6 signal transduction, including the transcriptional activation of acute-phase genes. Functions in brown adipose tissue (BAT) differentiation (By similarity) Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG) (By similarity) | |
| Cellular Location Nucleus. | |
| Tissue Location Liver and lung. | |
C/EBP Beta Antibody (C-term) - Application data
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A. Western blot analysis on PC-12 cell lysate using anti-C/EBP Beta RabMAb (Cat. #AJ1110a), dilution 1:5,000.
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B. Immunofluorescent staining of HeLa cells using anti-C/EBP Beta RabMAb (Cat. #AJ1110a).
C/EBP Beta Antibody (C-term) - Related products
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
CCAAT/enhancer-binding proteins (C/EBP) consist of a family of transcription factors that play an important role in regulating the balance between cell growth & differentiation. The various isoforms of C/EBP (α,β,γ,δ,ε, ζ ) exhibit similar DNA-binding specificities and contain a leucine zipper dimerization domain (1). A number of serine targets of PKA have been identified in C/EBP-β, suggesting its activities are post-translationally regulated by cAMP (2). Even though, it has been show that C/EBP β occurs predominantly as a heterodimer (3), C/EBP β & γ readily heterodimerize with each other as well as with C/EBP α (4). Additionally, 3 isoforms of C /EBP β can be detected (LAP*, LAP, & LIP) (5).
REFERENCES
1. Julie Lekstrom-Himes and Kleanthis G. Xanthopoulos, J Biol Chem, Vol. 273, Issue 44, 28545-28548, October 30, 1998
2. Brasier AR, and Li J. Mechanisms for Inducible Control of Angiotensinogen Gene Transcription. Hypertension 27:465-475 (1996).
3. Sara E. Parkin , Mark Baer , Terry D. Copeland, Richard C. Schwartz , and Peter F. Johnson, J. Biol. Chem., Vol. 277, Issue 26, 23563-23572, June 28, 2002
4. H Thomassin, D Hamel, D Bernier, M Guertin and L Belanger. Nucleic Acids Research, Vol 20, Issue 12 3091-3098, 1992
5. Wen-Chi Su, et al. J. Biol. Chem., Vol. 278, Issue 51, 51150-51158, December 19, 2003
