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Calmodulin Antibody (CaM) (C-term)Rabbit Monoclonal Antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AJ1118a | 100ul 400 ul | 2-3 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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Calmodulin Antibody (CaM) (C-term) - Product info | |
| Application | WB, IHC
|
| Primary Accession | P62158 |
| Reactivity | Human, Mouse, Rat |
| Clone Names | EP799Y |
| Calculated MW | 16838 Da |
| Gene ID 808 | |
| Other Names CALM3, CALML2, CAM3, CAMC, CAMIII, Calmodulin | |
| Target/Specificity A synthetic peptide corresponding to residues in the C-terminus of human Calmodulin was used as immunogen. | |
| Dilution WB~~1:1000~2000 IHC~~1:250~500 | |
| Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions Calmodulin Antibody (CaM) (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
Calmodulin Antibody (CaM) (C-term) - Protein Information | |
| Name CALM1 | |
| Synonyms CALM, CAM, CAM1 | |
| Function Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis | |
| Cellular Location Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules | |
Calmodulin Antibody (CaM) (C-term) - Related products
AP1570b: Calmodulin Antibody (C-term)
AP8549b: CALM1 Antibody (C-term)
RI10751: CALM1 predesign siRNA
RI10752: CALM2 predesign siRNA
RI10753: CALM3 predesign siRNA
BP1570b: Calmodulin Antibody (C-term) Blocking Peptide
Calmodulin Antibody (CaM) (C-term) - Application data
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A. Western blot analysis on NIH 3T3 cell lysate using anti-Calmodulin (C-term) RabMAb (Cat. #AJ1118a), dilution 1:5,000
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B. Immunohistochemical analysis of paraffin-embedded human urinary bladder carcinoma using anti-Calmodulin RabMAb (Cat. #AJ1118a).
Calmodulin Antibody (CaM) (C-term) - Research Areas
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BACKGROUND
Calmoduin (CaM) is a calcium modulator protein and a transducer of calcium signals (1-2). Upon calcium binding, calmodulin undergoes conformational changes and binds and modulates a diverse array of proteins. Calcium-bound CaM (Ca2+-CaM) can assume a variety of shapes depending on the target (3). Ca2+-CaM binds many kinases, phosphatases, signaling proteins, and structural proteins affecting a wide variety of processes including neurotransmitter release, muscle contraction, metabolism, apoptosis, inflammation, membrane protein organization, and cytoskeleton movement (2, 4-5).
REFERENCES
1. Sasagawa T, Ericsson LH, Walsh KA, Schreiber WE, Fischer EH, Titani K. Biochemistry. 1982 May 11;21(10):2565-9.
2. Eldik L.V. and Watterson,D.M. (1998) Academic Press, San Diego, CA
3. Finn B.E., Evenas,J., Drakenberg,T., Waltho,J.P., Thulin,E. and Forsen,S. (1995) Nat. Struct. Biol., 2, 777
4. DeMaria C.D., Soong,T.W., Alseikhan,B.A., Alvania,R.S. and Yue,D.T. (2001) Nature, 411, 484
5. Deisseroth K., Heist,E.K. and Tsien,R.W. (1998) Nature, 392, 198
