|Application ||WB, IHC|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||28316 Da|
|Other Names||Calpain small subunit 1, CSS1, Calcium-activated neutral proteinase small subunit, CANP small subunit, Calcium-dependent protease small subunit, CDPS, Calcium-dependent protease small subunit 1, Calpain regulatory subunit, CAPNS1, CAPN4, CAPNS|
|Target/Specificity||A synthetic peptide corresponding to residues in human Calpain 1 (small subunit) was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Calpain-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.|
|Cellular Location||Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon calcium binding.|
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Provided below are standard protocols that you may find useful for product applications.
Calcium-dependent cysteine proteinases, or calpains, are widely distributed in mammalian cells. There are 2 distinct molecular forms, calpains 1 and 2, which differ in the quantity of calcium required. Both calpains 1 and 2 are heterodimeric; each is composed of 1 heavy (about 80 kD), CAPN1 and CAPN2, respectively, and 1 shared light (about 30 kD) subunit, CAPNS1. The heavy subunit has a catalytic function, and the light subunit is regulatory.
1. Online Mendelian Inheritance in Man (OMIM), John Hopkins University, Calpain, small subunit 1; CAPNS1 (114170)
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