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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Calponin-1 Antibody (C-term)   

Calponin-1 Antibody (C-term)

Rabbit Monoclonal Antibody

  • WB - Calponin-1 Antibody (C-term) AJ1123a
    A. Western blot analysis on human bladder lysate using anti-Calponin RabMAb (Cat. #AJ1123a), dilution 1:20,000
  • IHC - Calponin-1 Antibody (C-term) AJ1123a
    B. Immunohistochemical staining of paraffin-embedded human smooth muscle using anti-Calponin RabMAb (Cat. #AJ1123a).
  • IF - Calponin-1 Antibody (C-term) AJ1123a
    C. Immunofluorescent staining of Hela cells using anti Calponin-1 RabMAb(Cat. #AJ1123a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P51911
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP798Y
Calculated MW 33170 Da
Gene ID 1264
Other Names Calponin-1, Basic calponin, Calponin H1, smooth muscle, CNN1
Target/Specificity A synthetic peptide corresponding to residues near the C-term of human Calponin was used as an immunogen.
Dilution WB~~1:20000~100000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCalponin-1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CNN1
Function Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity).
Tissue Location Smooth muscle, and tissues containing significant amounts of smooth muscle
Research Areas
Citations (0)

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Calponin is a smooth muscle specific, actin-, tropomyosin- and calmodulin-binding protein thought to be involved in regulation of actomyosin as well as the regulation or modulation of contraction (1). Calponin binds filamentous actin (F-actin) through two distinct sites ABS1 and ABS2, with an affinity in the low micromolar range (2) Immunoreactivity for calponin, along with alpha-smooth muscle actin and smooth muscle myosin heavy chains, confirms the known neoplastic myoepithelial component of adenoid cystic carcinomas and epithelial-myoepithelial carcinomas. The consistently positive staining pattern in adenoid cystic carcinomas may be diagnostically useful in discriminating histologically similar but consistently negative polymorphous low-grade adenocarcinomas (3).


1. Strasser P, et al. FEBS Lett. 330(1):13-8, 1993
2. Ferjani I, et al. FEBS Lett. 580(20):4801-6, 2006
3. Prasad AR, et al. Arch Pathol Lab Med. 123(9): 801-6, 1999

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Cat# AJ1123a
(40 western blots)
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