|Reactivity||Human, Mouse, Rat|
|Calculated MW||31540 Da|
|Other Names||Calretinin, CR, 29 kDa calbindin, CALB2, CAB29|
|Target/Specificity||A synthetic peptide corresponding to residues near the N-terminus of human Calretinin was used as an immogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Calretinin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calretinin is a calcium-binding protein which is abundant in auditory neurons.|
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Provided below are standard protocols that you may find useful for product applications.
Calretinin (CAB29, calbindin 2) is a calcium binding protein that belongs to calbindin family. It is mainly found in neuronal tissue, high expressed in auditory neurons. It has been implicated in as a calcium buffer, calcium sensor, and as a regulator of apoptosis (1). Calretinin is considered as a specific marker of mesothelllal cells; it is the only marker that has the utility in distinguishing between sarcomatoid mesotheliomas and sarcomatoid renal cell carcinomas (2). It is widely used in the panel of makers for distinguishing mesothlioma from adenocarcinoma. Along with calretinin, the panel includes E-cadherin and cytokeratin 5/6 (3).
1. Plattelli A et al. J Endocl 29(6):394-396, 2003
2. Ordonez NG et al. Hum Pathol. 35(6):697-710, 2004
3. Ordonez NG et al. Hum Pathol. 30(3):313-23. 1999
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