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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CaMKII Antibody   

CaMKII Antibody

Rabbit Monoclonal Antibody

  • WB - CaMKII Antibody AJ1127a
    A. Western blot analysis on (A) mouse brain and (B) rat brain lysates using anti-CaMKII RabMAb (Cat. #AJ1127a), dilution 1:20,000.
  • IHC - CaMKII Antibody AJ1127a
    B. Immunohistochemical staining of paraffin-embedded human brain carcinoma using anti-CaMKII RabMAb (Cat. #AJ1127a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UQM7
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP1829Y
Calculated MW 54088 Da
Gene ID 815
Other Names Calcium/calmodulin-dependent protein kinase type II subunit alpha, CaM kinase II subunit alpha, CaMK-II subunit alpha, CAMK2A, CAMKA, KIAA0968
Target/Specificity A synthetic peptide corresponding to residues on human CaMKII was used as an immunogen. The peptide immunogen is highly conserved between CaMKII-alpha, -beta, -gamma, and -omega.
Dilution WB~~1:1000~5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCaMKII Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CAMKA, KIAA0968
Function CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).
Cellular Location Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse Note=Postsynaptic lipid rafts.
Research Areas
Citations (0)

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Calcium/calmodulin-dependent protein kinase II (CaMKII) is a widely distributed protein kinase that regulates numerous physiological functions. Inhibitors of CaMKII are useful tools for investigating the CaMKII functions (1). The synapse contains densely localized and interacting proteins that enable it to adapt to changing inputs. A Ca2+-sensitive protein complex involved in the regulation of AMPA receptor synaptic plasticity. The complex is comprised of MUPPI, a multi-PDZ domain-containing protein; SynGAP, a synaptic GTPase-activating protein; and the Ca2+/calmodulin-dependent kinase CaMKII. In synapses of hippocampal neurons, SynGAP and CaMKII are brought together by direct physical interaction with the PDZ domains of MUPP1, and in this complex, SynGAP is phosphorylated. Ca2+CaM binding to CaMKII dissociates it from the MUPP1 complex, and Ca2+ entering via the NMDAR drives the dephosphorylation of SynGAP (2).


1. Krapivinsky G, et al. Neuron 43(4):563-74, 2004
2. Zhang J, et al. Biochem Biophys Res Commun 285(2): 229-34, 2001

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Cat# AJ1127a
(40 western blots)
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