|Application ||WB, IF, IHC|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||24942 Da|
|Other Names||Casein kinase II subunit beta, CK II beta, Phosvitin, Protein G5a, CSNK2B, CK2N, G5A|
|Target/Specificity||A synthetic peptide corresponding to residues near the C-terminal of human CKII beta protein was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CSNK2B Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.|
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Provided below are standard protocols that you may find useful for product applications.
Casein Kinase II (CKII, CK2, phosvitin kinase, troponin T kinase, casein kinase G) is a ubiquitous serine/threonine protein kinase that is highly conserved and commonly found in eukaryotic cells (found in the cytoplasm and the nucleus). CKII is a heterotetramer that consists of two catalytic subunits (alpha, alpha-prime) and two regulatory beta subunits (1). CKII can utilize both GTP and ATP as the phosphate donor and phosphorylates threonine and serine residues. Therefore, CKII is a multifunctional protein kinase with broad range of substrates (e.g. c-Myc, c-Myb, c-Fos, c-Jun, p53, Rb, HPVE7) and it has been implicated in various cell functions/processes from cell transformation to mitosis. (2)
1. Jakobi R. et al. Europ. J. Biochem. 183: 227-233, 1989
2. Donella-Deana A. et al. Biochem J., 357:563-567, 2001.
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