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Catenin (p120) Antibody Phospho (pY228)Rabbit Monoclonal Antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AJ1138a | 100ul 400 ul | 2-3 days | $ 355.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
Catenin (p120) Antibody Phospho (pY228) - Product info | |
| Application | WB, IHC
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| Primary Accession | O60716 |
| Reactivity | Human, Mouse, Rat |
| Clone Names | E205 |
| Calculated MW | 108170 Da |
| Gene ID 1500 | |
| Other Names CTNND1, KIAA0384, Catenin delta-1, p120(cas) | |
| Target/Specificity A synthetic phospho-peptide corresponding to residues surrounding Tyr228 of human p120 Catenin was used as immunogen. The antibody only detects p120 Catenin phosphorylated on Tyrosine 228. | |
| Dilution WB~~1:1000 IHC~~1:50 | |
| Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions Catenin (p120) Antibody Phospho (pY228) is for research use only and not for use in diagnostic or therapeutic procedures. | |
Catenin (p120) Antibody Phospho (pY228) - Protein Information | |
| Name CTNND1 | |
| Synonyms KIAA0384 | |
| Function Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- and E-cadherins Implicated both in cell transformation by SRC and in ligand- induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage | |
| Cellular Location Cytoplasm. Nucleus. Cell membrane. Note=Interaction with GLIS2 promotes nuclear translocation (By similarity). Detected at cell-cell contacts. NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm | |
| Tissue Location Expressed in vascular endothelium. | |
Catenin (p120) Antibody Phospho (pY228) - Related products
AJ1138a: Catenin (p120) Antibody Phospho (pY228)
AJ1138b: Catenin (p120) Antibody Phospho (pY291)
AJ1563a: p120 (Catenin) Antibody Phospho (pY96)
AJ1563b: p120 Catenin Antibody
AJ1563c: p120 Catenin Antibody
AJ1563d: p120 Catenin Antibody Phospho (pS268)
Catenin (p120) Antibody Phospho (pY228) - Application data
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A. Western blot analysis on HeLa cell lysate using anti- Phospho-p120 Catenin (Y228) RabMAb (Cat. #AJ1138a), dilution 1:5,000-20,000. Cell lysates were (1) untreated, (2) treated with Pervanadate, or (3) treated with Phosphatase.
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B. Immunohistochemical analysis of paraffin-embedded breast carcinoma using anti-Phospho-p120 Catenin (Y228) RabMAb (Cat. #AJ1138a).
Catenin (p120) Antibody Phospho (pY228) - Research Areas
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BACKGROUND
Catenins are proteins that are linked to the cytoplasmic domain of transmembrane cadherins. p120 Catenin is one member of this Armadillo gene family of junctional plaque proteins (1-3). The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be important for cadherins cell-adhesion properties. Recently it became clear that some catenins also mediate nuclear signaling (1). p120 Catenin is implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors.
REFERENCES
1. Keirsebilck, A., et al. Molecular cloning of the human p120ctn catenin gene (CTNND1): expression of multiple alternatively spliced isoforms. Genomics 50: 129
2. Aho, S., et al. Specific sequences in p120ctn determine subcellular distribution of its multiple isoforms involved in cellular adhesion of normal and malignant epithelial cells. J Cell Sci. 115: 1391
3. van Hengel, J., et al. Nuclear localization of the p120(ctn) Armadillo-like catenin is counteracted by a nuclear export signal and by E-cadherin expression. Proc Natl Acad Sci U S A. 96: 7980
