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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Cathepsin D Antibody   

Cathepsin D Antibody

Rabbit Monoclonal Antibody

  • WB - Cathepsin D Antibody AJ1139a
    A.Western blot analysis on (A) MCF-7 and (B) SKBR3 cell lysate using anti-cathepsin D RabMAb (Cat. #AJ1139a), dilution 1:2000.
  • IHC - Cathepsin D Antibody AJ1139a
    B. Immunohistochemical analysis of paraffin-embedded human liver using anti-Cathepsin D RabMAb (Cat. #AJ1139a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P07339
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR3056Y
Calculated MW 44552 Da
Gene ID 1509
Other Names Cathepsin D, Cathepsin D light chain, Cathepsin D heavy chain, CTSD, CPSD
Target/Specificity A synthetic peptide corresponding to residues near the N-terminus of human Cathepsin D was used as an immunogen.
Dilution WB~~1:1000~2000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCathepsin D Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CPSD
Function Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
Cellular Location Lysosome. Melanosome. Secreted, extracellular space. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380).
Tissue Location Expressed in the aorta extrcellular space (at protein level).
Research Areas
Citations (0)

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Cathepsin D is a ubiquitously expressed lysosomal protease that is involved in proteolytic degradation, cell invasion, and apoptosis (1). It is suspected to play important roles in protein catabolism, antigen processing, degenerative diseases, and breast cancer progression (2). Cathepsin D is induced by estrogens in mammary cancer cells where its concentration is correlated with a higher risk of metastasis (3). It is possibly involved in Alzheimer's disease-related neurodegeneration through cleavage of amyloid precursor protein into amyloidogenic components (4). Preprocathepsin D (43 kDa) is cleaved and glycosylated to form procathepsin D (46 kDa), and then further cleaved, forming light and a heavy chains (15 kDa and 28 kDa, respectively) (5).


1. Steinfeld R, et al. Am J Hum Genet. 78(6):988-98, 2006
2. Baldwin ET, et al. Proc Natl Acad Sci U S A. 90(14):6796-800, 1993
3. Augereau P, et al. Mol Endocrinol. 8(6):693-703, 1994
4. Papassotiropoulos A, et al. Ann Neurol. 47(3):399-403,2000
5. Shewale JG, et al. PNAS 81(12): 3703-3707, 1984-06

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Cat# AJ1139a
(40 western blots)
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