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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   GPCR Antibodies   >   CCR7/CKR7 Antibody (N-term)   

CCR7/CKR7 Antibody (N-term)

Rabbit Monoclonal Antibody

  • WB - CCR7/CKR7 Antibody (N-term) AJ1144b
    A. Western blot analysis on (left) K562 and (right) Daudi cell lysates using anti-CKR7/CCR7 (N-term) RabMAb (Cat. #AJ1144b), dilution 1:5,000.
  • IHC - CCR7/CKR7 Antibody (N-term) AJ1144b
    B. Immunohistochemical analysis of paraffin-embedded human spleen using anti-CKR7/CCR7 (N-term) RabMAb (Cat. #AJ1144b).
  • IF - CCR7/CKR7 Antibody (N-term) AJ1144b
    C. Immunofluorescent staining of HeLa cells using anti-CKR7/CCR7 (N-term) RabMAb (Cat. #AJ1144b).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P32248
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names Y59
Calculated MW 42874 Da
Gene ID 1236
Other Names C-C chemokine receptor type 7, C-C CKR-7, CC-CKR-7, CCR-7, BLR2, CDw197, Epstein-Barr virus-induced G-protein coupled receptor 1, EBI1, EBV-induced G-protein coupled receptor 1, MIP-3 beta receptor, CD197, CCR7, CMKBR7, EBI1, EVI1
Target/Specificity A synthetic peptide corresponding to residues in N-terminal extracellular domain of human CKR7 was used as immunogen. The antibody does not cross-react with other G-protein coupled receptor 1 family members.
Dilution WB~~1:10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCCR7/CKR7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCR7
Synonyms CMKBR7, EBI1, EVI1
Function Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7
Research Areas
Citations (0)

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CKR7, or C-C chemokine receptor type 7, is a G protein-coupled, seven-transmembrane domain receptor protein. Originally identified as the EBV-induced gene-1 (1), CKR7 was later found to be the receptor for the chemokines CCL21 (SLC, 6Ckine, Exodus-2) (3) and CCL19 (MIP-3 beta, Exodus-3, ELC) (4). CCR7 is expressed in lymphoid tissues and activated B and T lymphocytes (2). It is up-regulated in B cells infected with Epstein-Barr virus and T cells infected with herpesvirus 6 or 7 (4).


1. Schweickart, V. L., et al. Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2. Genomics. 23: 643-50 (1994).
2. Birkenbach, M., et al. Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors. J. Virol. 67: 2209-20 (1993).
3. Yoshida, R., et al. Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7. J. Biol. Chem. 273: 7118-22 (1998).
4. Yoshida, R., et al. Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7. J. Biol. Chem. 272: 13803-9 (1997).

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Cat# AJ1144b
(40 western blots)
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