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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   GPCR Antibodies   >   CCR8/CKR8 Antibody (C-term)   

CCR8/CKR8 Antibody (C-term)

Rabbit Monoclonal Antibody

  • WB - CCR8/CKR8 Antibody (C-term) AJ1145a
    A. Western blot analysis on Jurkat cell lysates using anti-CKR8/CCR8 (C-term) RabMAb (Cat. #AJ1145a), dilution 1:500.
  • IF - CCR8/CKR8 Antibody (C-term) AJ1145a
    B. Immunofluorescent staining of HeLa cells using anti- CKR8/CCR8 (C-term) RabMAb (Cat. #AJ1145a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P51685
Reactivity Human, Mouse
Host Rabbit
Clonality Monoclonal
Clone Names E76
Calculated MW 40844 Da
Gene ID 1237
Other Names C-C chemokine receptor type 8, C-C CKR-8, CC-CKR-8, CCR-8, CC chemokine receptor CHEMR1, CMKBRL2, Chemokine receptor-like 1, CKR-L1, GPR-CY6, GPRCY6, TER1, CDw198, CCR8, CKRL1, CMKBR8, CMKBRL2
Target/Specificity A synthetic peptide corresponding to residues near C-terminus of human CKR8 was used as immunogen. The antibody does not cross-react with other G-protein coupled receptor 1 family members.
Dilution WB~~1:500
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCCR8/CKR8 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCR8
Function Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.
Cellular Location Cell membrane; Multi-pass membrane protein.
Research Areas
Citations (0)

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CKR8/CCR8, or C-C chemokine receptor type 8, is a G protein-coupled, seven-transmembrane domain receptor protein. Chemokines are key molecules in directing leukocyte migration toward sites of inflammation. The human C-C chemokine I-309 is a monocyte chemoattractant and inhibits apoptosis in thymic cell lines. It has been found that CKR8/CCR8 is a receptor for chemokines SCYA1/I-309, SCYA4/MIP-1-beta, and SCYA17/TARC (1-3).


1. Tiffany, H.L., et al. Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309. J. Exp Med. 186: 165
2. Goya, I., et al. Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3. J Immunol. 160: 1975-81 (1998).
3. Bernardini, G., et al. Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor. Eur J Immunol. 28: 582

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Cat# AJ1145a
(40 western blots)
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