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CCR9/CKR9 Antibody (N-term)

Rabbit Monoclonal Antibody

     
  • WB - CCR9/CKR9 Antibody (N-term) AJ1146a
    A. Western blot analysis on (1) K562 and (2) Daudi cell lysates using anti-CKR9/CCR9 (N-term) RabMAb (Cat. #AJ1146a), dilution 1:500.
  • FC - CCR9/CKR9 Antibody (N-term) AJ1146a
    B. Flow cytometric analysis of K562 cells using anti-CKR9 RabMAb (red) (Cat. #AJ1146a) or a rabbit IgG (negative) (green).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC
Primary Accession P51686
Reactivity Human, Mouse
Host Rabbit
Clonality Monoclonal
Clone Names E99
Calculated MW 42016 Da
Gene ID 10803
Other Names C-C chemokine receptor type 9, C-C CKR-9, CC-CKR-9, CCR-9, G-protein coupled receptor 28, GPR-9-6, CDw199, CCR9, GPR28
Target/Specificity A synthetic peptide corresponding to N-terminal residues (extracellular domain) of human CKR9 was used as immunogen. The antibody does not cross-react with other G-protein coupled receptor 1 family members.
Dilution WB~~1:1000~10000
FC~~1:50
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCCR9/CKR9 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCR9
Synonyms GPR28
Function Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Highly expressed in the thymus and low in lymph nodes and spleen.
Research Areas
Citations (0)

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Background

CKR9/CCR9 (C-C chemokine receptor type 9), also designated GPR-9-6, is a G protein-coupled, seven-transmembrane domain receptor protein. It has been found that CKR9/CCR9 is a receptor for the thymus expressed chemokine TECK (1,2). CKR9/CCR9 and TECK are thought to play a specialized role in the immune response because both are highly expressed by T lymphocytes in the small intestine, where they are not in other tissues (2,3).

References

1. Zaballos, A., et al. Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK. J Immunol. 162: 5671-5 (1999).
2. Zabel, B.A., et al. Human G protein-coupled receptor GPR-9-6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxis. J Exp
3. Kunkel, E.J., et al. Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regi

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Discontinued
Cat# AJ1146a
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