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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CD11b/ITAM Antibody   

CD11b/ITAM Antibody

Rabbit Monoclonal Antibody

  • WB - CD11b/ITAM Antibody AJ1149a
    A. Western blot analysis on TF-1 lysate using anti-ITAM RabMAb (Cat. #AJ1149a), dilution 1:20,000
  • IHC - CD11b/ITAM Antibody AJ1149a
    B. Immunohistochemical analysis of paraffin-embedded human spleen using anti-ITAM RabMAb (Cat. #AJ1149a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P11215
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP1345Y
Calculated MW 127179 Da
Gene ID 3684
Other Names Integrin alpha-M, CD11 antigen-like family member B, CR-3 alpha chain, Cell surface glycoprotein MAC-1 subunit alpha, Leukocyte adhesion receptor MO1, Neutrophil adherence receptor, CD11b, ITGAM, CD11B, CR3A
Target/Specificity A synthetic peptide corresponding to C-terminus of human CD11b/ITAM protein was used as immunogen
Dilution WB~~1:500
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCD11b/ITAM Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CD11B, CR3A
Function Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Predominantly expressed in monocytes and granulocytes
Research Areas
Citations (0)

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Integrin alpha-M (ITAM, ITGAM, CD11b, MAC-1 alpha subunit, CR3 alpha chain) is the alpha subunit of ITAM/beta-2 complex (CD11b/CD18, Mac-1), a leukocyte adhesion heterodimeric glycoprotein (1). ITAM belongs to integrin alpha chain family and it is predominately presented in human myeloid cells, NK1 cells, monocytes, and granulocytes. ITAM/beta-2 complex is a receptor for fibrinogen (binding to P1 and P1 peptides of gamma chain), factor X, and ICAM1. ITAM/beta-2 is implicated in adhesive interactions of monocytes, macrophages, and granulocytes. It is also linked to mediation of complement-coated particle uptake (2).


1. Corbi AL et al. J. Biol. Chem. 263(25):12403-12411, 1
2. Barden A et al. Clin Sci (Lond). 92(1):37-44m 1997.

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Cat# AJ1149a
(40 western blots)
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