|Application ||WB, IHC|
|Calculated MW||127829 Da|
|Other Names||Integrin alpha-X, CD11 antigen-like family member C, Leu M5, Leukocyte adhesion glycoprotein p150, 95 alpha chain, Leukocyte adhesion receptor p150, CD11c, ITGAX, CD11C|
|Target/Specificity||A synthetic peptide corresponding to residues on the C-terminus of human CD11c/ITGAX was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD11c (ITGAX) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Predominantly expressed in monocytes and granulocytes|
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Provided below are standard protocols that you may find useful for product applications.
Leukocyte surface antigen p150,95 (CD11c, ITGAX) shares a beta subunit with 2 other members of the leukocyte adhesion molecule family, Mac-1 and LFA-1, but has a unique alpha chain. The extracellular domain contains three tandem homologous repeats of approximately 60 amino acids with putative divalent cation-binding sites, and four weaker repeats which lack such binding sites. The ITGAX alpha subunit is homologous to the alpha subunits of receptors which recognize the RGD sequence in extracellular matrix components, as has previously been shown for the beta subunits, supporting the concept that receptors involved in both cell-cell and cell-matrix interactions belong to a single gene superfamily termed the integrins. Distinctive features of the ITGAX alpha subunit include an insertion of 126 residues N-terminal to the putative metal binding region and a deletion of the region in which the matrix receptors are proteolytically cleaved during processing (1). The alpha subunit of the leukocyte integrin p150,95 (CD11c) is a transmembrane polypeptide of 1144 residues whose long extracellular region contains three putative divalent cation binding repeats and a 200- amino acid inserted or I domain.
1. Corbi AL, et al. EMBO J 6(13):4023-8, 1987
2. Corbi AL, et al. J Biol Chem 265(21): 12750-1, 1990
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