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CD1a Antibody

Rabbit Monoclonal Antibody

  • WB - CD1a Antibody AJ1153a
    A. Western blot analysis on (A) mouse thymus, (B) MOLT4 and (C) K562 and (D) fetal thymus lysates using anti-CD1a RabMAb (Cat. #AJ1153a), dilution (A-C) 1:5000, (D) 1:200,000.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P06126
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP3091
Calculated MW 37077 Da
Gene ID 909
Other Names T-cell surface glycoprotein CD1a, T-cell surface antigen T6/Leu-6, hTa1 thymocyte antigen, CD1a, CD1A
Target/Specificity A synthetic peptide corresponding to residues on human CD1a was used as an immunogen.
Dilution WB~~1:5000~30000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCD1a Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD1A
Function Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
Cellular Location Cell membrane; Single-pass type I membrane protein. Endosome membrane. Note=Subject to intracellular trafficking between the cell membrane and endosomes. Localizes to cell surface lipid rafts
Tissue Location Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues.
Research Areas
Citations (0)

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The CD1 locus encodes a family of major histocompatibility complex (MHC) antigen-like glycoproteins which associate with beta 2-microglobulin and are expressed on immature thymocytes, Langerhans cells, and dendritic cells (1). Among five CD1 genes (a, b, c, d, e), CD1a, -b, and -c, have been clustered with monoclonal antibodies and may function as nonclassical antigen-presenting molecules (2). CD1a mediates T cell recognition of glycolipid and lipopeptide antigens that contain either one or two alkyl chains (3). CD1a molecules are expressed on dendritic cells during certain maturational phases coincident with the functions of antigen capture and processing (4). On thymocytes, CD1a forms noncovalent complexes with CD1b and CD1c, and a disulfide-linked heterodimer with CD8 (5).


1. S P Balk, et al. PNAS 86(1): 252-256, 1989
2. A Woolfson, et al. PNAS 91(14): 6683-6687, 1994
3. Zajonc DM, et al. Immunity. 22(2):209-19, 2005
4. Coventry B. J., et al. Anticancer research 19(4B): 3183-3187, 1999
5. Aruffo A, et al. J Immunol. 143(5):1723-30, 1989

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Cat# AJ1153a
(40 western blots)
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