|Calculated MW||37077 Da|
|Other Names||T-cell surface glycoprotein CD1a, T-cell surface antigen T6/Leu-6, hTa1 thymocyte antigen, CD1a, CD1A|
|Target/Specificity||A synthetic peptide corresponding to residues on human CD1a was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD1a Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.|
|Cellular Location||Cell membrane; Single- pass type I membrane protein. Membrane raft; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Note=Subject to intracellular trafficking between the cell membrane and endosomes (PubMed:11231314). Localizes to cell surface lipid rafts (PubMed:18178838).|
|Tissue Location||Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues.|
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Provided below are standard protocols that you may find useful for product applications.
The CD1 locus encodes a family of major histocompatibility complex (MHC) antigen-like glycoproteins which associate with beta 2-microglobulin and are expressed on immature thymocytes, Langerhans cells, and dendritic cells (1). Among five CD1 genes (a, b, c, d, e), CD1a, -b, and -c, have been clustered with monoclonal antibodies and may function as nonclassical antigen-presenting molecules (2). CD1a mediates T cell recognition of glycolipid and lipopeptide antigens that contain either one or two alkyl chains (3). CD1a molecules are expressed on dendritic cells during certain maturational phases coincident with the functions of antigen capture and processing (4). On thymocytes, CD1a forms noncovalent complexes with CD1b and CD1c, and a disulfide-linked heterodimer with CD8 (5).
1. S P Balk, et al. PNAS 86(1): 252-256, 1989
2. A Woolfson, et al. PNAS 91(14): 6683-6687, 1994
3. Zajonc DM, et al. Immunity. 22(2):209-19, 2005
4. Coventry B. J., et al. Anticancer research 19(4B): 3183-3187, 1999
5. Aruffo A, et al. J Immunol. 143(5):1723-30, 1989
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