|Application ||WB, IHC|
|Calculated MW||33077 Da|
|Other Names||B-lymphocyte antigen CD20, B-lymphocyte surface antigen B1, Bp35, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1, CD20, MS4A1, CD20|
|Target/Specificity||A synthetic peptide corresponding to residues in the C-term of human CD20 was used as immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD20 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This protein may be involved in the regulation of B-cell activation and proliferation.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor|
|Tissue Location||Expressed on B-cells.|
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Provided below are standard protocols that you may find useful for product applications.
CD20, also known as B1 and MS4A1, is a human B lymphocyte surface molecule expressed on both normal and malignant cells that functions as a receptor during B cell activation. It is also involved in the regulation of cell progression in B lymphocyrtes as either a component or a regulator of intracellular calcium levels (1-2). CD20 is phosphorylated on serines primarily and threonines but not tyrosines. Monoclonal antibodies against CD20 are used to treat B-cell non-Hodgkins lymphoma (3).
1. Tedder, T. F.; Klejman, G.; Schlossman, S. F.; Saito, H.: J. Immun. 142: 2560-2568, 1989.
2. Tedder, T. F.; Streuli, M.; Schlossman, S. F.; Saito, H.:Proc. Nat. Acad. Sci. 85: 208-212, 1988.
3. Fischer M, Behr T, Grunwald F, Knapp WH, Trumper L, von Schilling C; German Society for Hematology and Oncology, Nuklearmedizin. 2004 Oct;43(5):171-6.
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