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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   CD21 Antibody   

CD21 Antibody

Rabbit Monoclonal Antibody

  • WB - CD21 Antibody AJ1156a
    A. Western blot analysis on (A) Daudi, (B) Raji cell lysates using anti-CD21 RabMAb (Cat. #AJ1156a), dilution 1:2000
  • IHC - CD21 Antibody AJ1156a
    B. Immunohistochemical staining of paraffin-embedded tonsils using anti-CD21 RabMAb (Cat. #AJ1156a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P20023
Reactivity Human, Mouse
Host Rabbit
Clonality Monoclonal
Clone Names EP3093
Calculated MW 112916 Da
Gene ID 1380
Other Names Complement receptor type 2, Cr2, Complement C3d receptor, Epstein-Barr virus receptor, EBV receptor, CD21, CR2, C3DR
Target/Specificity A synthetic peptide corresponding to residues on the C terminus of human CD21 was used as an immunogen.
Dilution WB~~1:5000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCD21 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CR2
Synonyms C3DR
Function Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Mature B-lymphocytes, T-lymphocytes, pharyngeal epithelial cells, astrocytes and follicular dendritic cells of the spleen
Research Areas
Citations (0)

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CD21 is a single-pass type 2 transmembrane protein that serves as the complement receptor for C3d and the Epstein-Barr virus. It is a member of a family of C3b/C4b binding proteins that regulate complement activation, comprise tandemly repeated 60-75 amino acid sequences, and whose genes map to band q32 on chromosome 1 (1). CD21 interacts with the p53 anti-oncoprotein, the p68 calcium binding protein and the nuclear p120 ribonucleoprotein to regulate their functions. Phosphorylation of CD21 inhibits its interaction with the nuclear p120 ribonucleoprotein (2).


1. Weis JJ, et al. J Exp Med. 167(3):1047-66, 1988
2. Barel M, et al. Mol Immunol. 32(6):389-97, 1995

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Cat# AJ1156a
(40 western blots)
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