|Application ||WB, IHC|
|Calculated MW||36469 Da|
|Other Names||Low affinity immunoglobulin epsilon Fc receptor, BLAST-2, C-type lectin domain family 4 member J, Fc-epsilon-RII, Immunoglobulin E-binding factor, Lymphocyte IgE receptor, CD23, Low affinity immunoglobulin epsilon Fc receptor membrane-bound form, Low affinity immunoglobulin epsilon Fc receptor soluble form, FCER2, CD23A, CLEC4J, FCE2, IGEBF|
|Target/Specificity||A synthetic peptide corresponding to residues in human CD23 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD23 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CD23A, CLEC4J, FCE2, IGEBF|
|Function||Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).|
|Cellular Location||Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor. Secreted. Note=Also exists as a soluble excreted form, sCD23|
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Provided below are standard protocols that you may find useful for product applications.
CD23, a type II transmembrane glycoprotein, is a key molecule for B-cell activation and growth and functions as a receptor for IgE. It plays essential roles in the regulation of IgE production and in the differentiation of B-cells. CD21 has been identified as a ligand for CD23 in the control of IgE production. It is expressed in many haemopoietic cell types (1). CD23 expression is upregulated in B cell chronic lymphocyctic leukaemia and in some centroblastic/centrocytic lymphoma cases. CD23 is used in the differentiation of small lymphocytic lymphomas and mantle cell lymphoma (2).
1. Aubry JP et al. Nature 358, 505-507, 1992. 2. Dunphy CH et al. Mod Pathol 10(8): 818-822, 1997.
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