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CD23 AntibodyRabbit Monoclonal Antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AJ1158a | 100ul 400 ul | 2-3 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
CD23 Antibody - Product info | |
| Application | WB, IHC
|
| Primary Accession | P06734 |
| Reactivity | Human |
| Clone Names | EPR3617 |
| Calculated MW | 36469 Da |
| Gene ID 2208 | |
| Target/Specificity A synthetic peptide corresponding to residues in human CD23 was used as an immunogen. | |
| Dilution WB~~1:500 IHC~~1:100~250 | |
| Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions CD23 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
CD23 Antibody - Protein Information | |
| Name FCER2 | |
| Synonyms CD23A, CLEC4J, FCE2, IGEBF | |
| Function Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen) | |
| Cellular Location Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor. Secreted. Note=Also exists as a soluble excreted form, sCD23 | |
CD23 Antibody - Application data
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Western blot analysis on (A) Raji, (B) Lymph node and (C) human tonsil lysates using anti-CD23 RabMAb (Cat. #AJ1158a).
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Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti- CD23 RabMAb (Cat. #AJ1158a).
CD23 Antibody - Related products
RI11968: FCER2 predesign siRNA
LY10276a: FCER2 Over-expression Lysate
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
CD23, a type II transmembrane glycoprotein, is a key molecule for B-cell activation and growth and functions as a receptor for IgE. It plays essential roles in the regulation of IgE production and in the differentiation of B-cells. CD21 has been identified as a ligand for CD23 in the control of IgE production. It is expressed in many haemopoietic cell types (1). CD23 expression is upregulated in B cell chronic lymphocyctic leukaemia and in some centroblastic/centrocytic lymphoma cases. CD23 is used in the differentiation of small lymphocytic lymphomas and mantle cell lymphoma (2).
REFERENCES
1. Aubry JP et al. Nature 358, 505-507, 1992. 2. Dunphy CH et al. Mod Pathol 10(8): 818-822, 1997.
