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CD34 AntibodyRabbit Monoclonal Antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AJ1161a | 100ul 400 ul | 2-3 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
CD34 Antibody - Product info | |
| Application | WB, IHC
|
| Primary Accession | P28906 |
| Reactivity | Human |
| Clone Names | EP373Y |
| Calculated MW | 40716 Da |
| Gene ID 947 | |
| Other Names CD34, Hematopoietic progenitor cell antigen CD34 | |
| Target/Specificity A synthetic peptide corresponding to C-terminal of human CD34 was used as an immunogen | |
| Dilution WB~~1:10000~50000 IHC~~1:100 | |
| Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions CD34 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
CD34 Antibody - Protein Information | |
| Name CD34 | |
| Function Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins | |
| Cellular Location Membrane; Single-pass type I membrane protein | |
| Tissue Location Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues | |
CD34 Antibody - Related products
AM1825a: CD34 Antibody (Center)
AP10666c: CD34 Antibody (Center)
AP3600a: Phospho-CD34-pY330 Antibody
BP3600a: Phospho-CD34-pY330 Antibody Blocking Peptide
AT1434a: CD34 Antibody (monoclonal) (M01)
CD34 Antibody - Application data
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A. Western blot analysis on TF-1 using anti-CD34 RabMAb (Cat. #AJ1161a), 1:100,000.
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B. Immunohistochemical staining of paraffin-embedded human angiosarcoma using anti-CD34 RabMAb (Cat. #AJ1161a).
CD34 Antibody - Research Areas
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BACKGROUND
CD34 (Cluster of differentiation 34) is a single-pass type I transmembrane glycoprotein which primary functions as a cell to cell adhesion factor. As an adhesion factor, CD34 is expressed during stem/progenitor stage of lymphohematopoietic development and possibly mediates the stem cell attachment to the bone marrow ECM or stromal cells. CD34 is considered to be ideal marker for identifying and quantifying hematopoietic progenitor stem cells. With interaction with CrkL, CD34 becomes a substrate for PKC and CD34 surface expression is associated with activation of PKC.
REFERENCES
1. Sutherland DR, Keating A. J Hematother.1:115-129, 1992
2. Krause DS et al. Blood, 84(3);691-701, 1994
3. Felschow DM. et al. Blood 97;3768-3775, 2001
