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CD34 Antibody

Rabbit Monoclonal Antibody

  • WB - CD34 Antibody AJ1161a
    A. Western blot analysis on TF-1 using anti-CD34 RabMAb (Cat. #AJ1161a), 1:100,000.
  • IHC - CD34 Antibody AJ1161a
    B. Immunohistochemical staining of paraffin-embedded human angiosarcoma using anti-CD34 RabMAb (Cat. #AJ1161a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P28906
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP373Y
Calculated MW 40716 Da
Gene ID 947
Other Names Hematopoietic progenitor cell antigen CD34, CD34, CD34
Target/Specificity A synthetic peptide corresponding to C-terminal of human CD34 was used as an immunogen
Dilution WB~~1:10000~50000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCD34 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD34
Function Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues
Research Areas
Citations (0)

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CD34 (Cluster of differentiation 34) is a single-pass type I transmembrane glycoprotein which primary functions as a cell to cell adhesion factor. As an adhesion factor, CD34 is expressed during stem/progenitor stage of lymphohematopoietic development and possibly mediates the stem cell attachment to the bone marrow ECM or stromal cells. CD34 is considered to be ideal marker for identifying and quantifying hematopoietic progenitor stem cells. With interaction with CrkL, CD34 becomes a substrate for PKC and CD34 surface expression is associated with activation of PKC.


1. Sutherland DR, Keating A. J Hematother.1:115-129, 1992
2. Krause DS et al. Blood, 84(3);691-701, 1994
3. Felschow DM. et al. Blood 97;3768-3775, 2001

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Cat# AJ1161a
(40 western blots)
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