|Calculated MW||54578 Da|
|Other Names||T-cell surface glycoprotein CD5, Lymphocyte antigen T1/Leu-1, CD5, CD5, LEU1|
|Target/Specificity||A synthetic peptide corresponding to residues in human CD5 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May act as a receptor in regulating T-cell proliferation.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
CD5 (Lymphocyte antigen T1/Leu-1) is a transmembrane glycoprotein which has been implicated as a single-pass type I receptor in the regulation of T-cell proliferation (1). CD5 is part of the scavenger receptor cysteine-rich (SRCR) family group B and it is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. CD5 is also expressed by T cell leukemia, lymphomas, activated T cells, and occasionally a subset of B cells. Mantle cell lymphomas (same as diffuse centrocytic lymphomas) are CD5 positive while the follicle center cell lymphomas are CD5 negative. A ligand for CD72/LYB-2, CD5 has been linked to negative regulation of T cell and B cell receptors signaling (2).
1. Spertini F et al. Journal of Immunology, 146(1):47-52,1991
2. Perez-Villar JJ et al. Mol Cell Biol, 19(4):2903-2912, 1999
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.