|Application ||WB, IF, IHC|
|Calculated MW||94574 Da|
|Other Names||Neural cell adhesion molecule 1, N-CAM-1, NCAM-1, CD56, NCAM1, NCAM|
|Target/Specificity||A synthetic peptide corresponding to residues near the C-terminus of human NCAM/CD56 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD56/NCAM Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Cell membrane; Lipid-anchor, GPI- anchor Isoform 5: Secreted.|
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Provided below are standard protocols that you may find useful for product applications.
The neural cell adhesion molecule (NCAM/CD56) has been shown to mediate homophilic cell-cell adhesion in the neuroendocrine system with interactions among immunoglobulin-like domains. It is a multifunction transmembrane protein involved in synaptic plasticity, neurodevelopment, and neurogenesis. NCAM appears on early embryonic cells and is important in the formation of cell collectives and their boundaries at sites of morphogenesis (1-3). It is preferentially expressed on human NK cells and a subset of T lymphocytes that mediate MHC-unrestricted cell-mediated cytotoxicity (1). Single nucleotide polymorphisms (SNPs) in the NCAM gene are reported to be significantly associated with bipolar disorder in the Japanese population (3).
1. Lanier LL, et al. J Immunol. 146(12):4421-6, 1991
2. Cunningham BA, et al. Science. 236(4803):799-806, 1987
3. Atz M E, et al. Psychiatr Genet. 17 (2):55-67, 2007
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