|Application ||WB, IHC|
|Calculated MW||94574 Da|
|Other Names||Neural cell adhesion molecule 1, N-CAM-1, NCAM-1, CD56, NCAM1, NCAM|
|Target/Specificity||A synthetic peptide corresponding to residues in extracellular domain of human CD56/NCAM was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD56/NCAM Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Cell membrane; Lipid-anchor, GPI- anchor Isoform 5: Secreted.|
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The neural cell adhesion molecule (NCAM/CD56) is a homophilic binding glycoprotein belonging to immunoglobulin (Ig) superfamily. It is commonly found on the surface of neurons, NK cells, glia, and neuroendocrine tissues, and it is involved in synaptic plasticity, neurodevelopment, and neurogenesis. NCAM mediates axon growth, fasciculation, and cell adhesion by homophilic and heterophilic interactions (1). Due to alternative splicing, at least 27 different isoforms of NCAM mRNAs has been identified, leading to variety of NCAM isoforms (2). Three major NCAM isoforms are: 140 and 180 kDa transmembrane forms (NCAM-140, NCAM-180), and 120 kDa glycophosphatidylinositol (GPI)-linked isoform (NCAM120) (3).
1. BA Cunningham et al., Science 236(4803) 799-806, 1987 2. AA Reyes et al., Mol Cell Biol 11(3): 1654-1661, 1991. 3. HE Beggs et al., JCB 272(13):8310-8319, 1997.
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