|Calculated MW||40220 Da|
|Other Names||B-cell differentiation antigen CD72, Lyb-2, CD72, CD72|
|Target/Specificity||A synthetic peptide corresponding to residues in human CD72 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD72 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in B-cell proliferation and differentiation.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
|Tissue Location||Pre-B-cells and B-cells but not terminally differentiated plasma cells|
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Provided below are standard protocols that you may find useful for product applications.
CD72, a type II integral membrane glycopotein and a member of the C-type lectin family of cell surface receptors, is expressed in all stages of B cell development except in terminally differentiated plasma cells (1). Ligation of CD72 enhances B cell growth and differentiation. CD72 transmits positive signals through association with Grb2 and or CD19 and negative signals through association with SHP-1 (2 and 3). CD72 has been reported to bind to CD5, suggesting a role in regulating T-cell activation and proliferation (4). Disregulated expression of CD72 was related to disease such as lupus nephritis (5) and primary Sj鰃ren?s syndrome (6).
1. Von Hoegen et al, J Immunol, 144 (12): 4870-4877, 1990 2. Wu et al, Immunol Res, 25(2):155-66, 2002 3. Wu et al, J Clin Immunol, 29(1):12-21, 2009 4. Luo et al, J Immunol, 148 :1630-1634, 1992 5. Nakano et al, Autoimmunity, 40(1) :9-15, 2007 6. Smith et al. Tissue Antigens, 63(3) :255-9, 2004
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