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CD8 Antibody

Rabbit Monoclonal IgG

  • WB - CD8 Antibody AJ1170a
    Western blot analysis on A) MOLT-4, B) Jurkat cell lysates using anti-CD8 RabMAb (Cat. #AJ1170a).
  • IHC - CD8 Antibody AJ1170a
    Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-CD8 RabMAb (Cat. #AJ1170a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P01732
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP1150
Calculated MW 25729 Da
Gene ID 925
Other Names T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2, CD8a, CD8A, MAL
Target/Specificity A synthetic peptide corresponding to residues near the C-terminus of human CD8 Alpha chain was used as an immunogen.
Dilution WB~~1:2000~50000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCD8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD8A
Synonyms MAL
Function Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein
Research Areas
Citations (0)

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The T cell coreceptor CD8 is a cell-surface glycoprotein expressed either as a disulfide-linked homodimer of two CD8 alpha monomers, or a heterodimer of CD8 alpha and CD8 beta. These receptors interact with ligands, such as major histocompatibility complex (MHC) class I, on the outside of the cell, with proteins inside the cell, such as the tyrosine kinase p56lck, and possibly with proteins on the same cell-surface (1). CD8 plays an important role in T cell development in the thymus and T cell activation in the periphery (2).


1. Devine L, et al. Immunol Res, 19(2-3):201-10, 1999. 2. Wong, JS, et al. J Immunol 171:867-874, 2003

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Cat# AJ1170a
(40 western blots)
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