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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CDX2 Antibody   

CDX2 Antibody

Rabbit Monoclonal Antibody

  • WB - CDX2 Antibody AJ1181a
    A. Western blot analysis on (A) HT29, (B) colon cancer and (C) human small intestine lysates using anti-CDX-2 RabMAb (Cat. #AJ1181a), dilution (A) 1:1000 and (B, C) 1:5000.
  • IHC - CDX2 Antibody AJ1181a
    B. Immunohistochemical analysis of paraffin-embedded human gastric adenocarcinoma using anti-CDX-2 RabMAb (Cat. #AJ1181a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q99626
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR2764Y
Calculated MW 33520 Da
Gene ID 1045
Other Names Homeobox protein CDX-2, CDX-3, Caudal-type homeobox protein 2, CDX2, CDX3
Target/Specificity A synthetic peptide corresponding to residues near the N-terminus of human CDX-2 was used as an immunogen.
Dilution WB~~1:2000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCDX2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDX2
Synonyms CDX3
Function Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.
Cellular Location Nucleus.
Research Areas
Citations (0)

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The caudal-related homeodomain protein 2, CDX-2, is a transcription factor which is expressed in the intestine and is thought to play an important role in the proliferation and differentiation of intestinal epithelial cells. The CDX-2 protein is expressed in primary and metastatic colorectal carcinomas, intestinal metaplasia of the stomach and intestinal type gastric cancer. In human colorectal cancer, the expression of both CDX2 and carbonic anhydrase 1, a gene regulated by CDX2, is reduced or absent. (1). CDX-2 is one of the important regulators in defining pathways for coordinate control of drug metabolism in the gastrointestinal tract (2).


1. Drummond F, et al. Ann Hum Genet 61(5):393-400
2. Gregory PA, et al. Pharmacogenet Genomics 16(7):527-36, 2006

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Cat# AJ1181a
(40 western blots)
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