|Application ||WB, IHC|
|Calculated MW||13075 Da|
|Other Names||Glycoprotein hormones alpha chain, Anterior pituitary glycoprotein hormones common subunit alpha, Choriogonadotropin alpha chain, Chorionic gonadotrophin subunit alpha, CG-alpha, Follicle-stimulating hormone alpha chain, FSH-alpha, Follitropin alpha chain, Luteinizing hormone alpha chain, LSH-alpha, Lutropin alpha chain, Thyroid-stimulating hormone alpha chain, TSH-alpha, Thyrotropin alpha chain, CGA|
|Target/Specificity||A synthetic peptide corresponding to residues at the C terminus of human CGA was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CGA Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.|
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Provided below are standard protocols that you may find useful for product applications.
CGA belongs to the glycoprotein hormone alpha chain family that includes the alpha subunit of chronic gonadotropin (CG), lutenizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH). The glycoprotein hormones have the most complex chemical structures of the classical protein hormones. They are dimers consisting of alpha and beta subunits that are associated noncovalently (1, 4). The alpha subunit is common to all of the hormones; however, their beta chains are unique and confer biological specificity (1). These hormones are central to the complex endocrine system that regulates normal growth, sexual development, and reproductive function (2). The hormones LH, FSH and TSH are secreted by the anterior pituitary gland, while CG is secreted by the placenta (3).
1. The UniProt Consortium. The Universal Protein Resource (UniProt). Nucleic Acids Res. 36:D190-D195 (2008). 2. Godine et al. J. Biol. Chem. 257 :8368-71 ; 1982 3. Golos et al. DNA Cell Biol. 10 :367-80 ; 1991 4. Ryan, R.J., et al. The FASEB Journal 2:2661-2669, 1988
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