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CGB Antibody

Rabbit Monoclonal IgG

     
  • WB - CGB Antibody AJ1184a
    Western blot analysis on (A) JAR and (B) NCCIT cell lysates using anti-CGB RabMAb (Cat. #AJ1184a).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P01233
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR3376
Other Names Choriogonadotropin subunit beta, CG-beta, Chorionic gonadotrophin chain beta, CGB, CGB3
Target/Specificity A synthetic peptide corresponding to residues in human CGB was used as an immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCGB Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Research Areas
Citations (0)

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Background

Human chorionic gonadotropin beta (CGB) belongs to the glycoprotein hormone family that includes the beta subunit of lutenizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) (1). These hormones are central to the endocrine system that regulates normal growth, sexual development, and reproductive function (2). HCG primarily maintains the myometrial and decidual spiral arteries, or the vascular supply of the placenta during the full course of pregnancy (3). It is mainly secreted by the endocrine villous cytotrophoblasts into the maternal compartment and stimulates the formation of the syncytiotrophoblast in an autocrine manner (4). Then HCG binds to the corpus luteum of the ovary, which is stimulated to produce progesterone and maintain the secretory endometrium (5). CGB confers biological specificity, whereas the alpha subunit of HCG is common to all glycoprotein hormones (1).

References

1. The UniProt Consortium. The Universal Protein Resource (UniProt). Nucleic Acids Res. 36:D190-D195 (2009). 2. Godine et al. J. Biol. Chem. 257:8368-71,1982. 3. Cole LA. Expert Rev Mol Diagn. 9(7):721-47, 2009. 4. Handschuh K et al. Placenta. 30(12):1016-22, 2009. 5. Stenman UH et al. Hum Reprod Update. 12(6):769-84, 2006.

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Discontinued
Cat# AJ1184a
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