|Calculated MW||17739 Da|
|Other Names||Choriogonadotropin subunit beta, CG-beta, Chorionic gonadotrophin chain beta, CGB, CGB3|
|Target/Specificity||A synthetic peptide corresponding to residues in human CGB was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CGB Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.|
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Provided below are standard protocols that you may find useful for product applications.
Human chorionic gonadotropin beta (CGB) belongs to the glycoprotein hormone family that includes the beta subunit of lutenizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) (1). These hormones are central to the endocrine system that regulates normal growth, sexual development, and reproductive function (2). HCG primarily maintains the myometrial and decidual spiral arteries, or the vascular supply of the placenta during the full course of pregnancy (3). It is mainly secreted by the endocrine villous cytotrophoblasts into the maternal compartment and stimulates the formation of the syncytiotrophoblast in an autocrine manner (4). Then HCG binds to the corpus luteum of the ovary, which is stimulated to produce progesterone and maintain the secretory endometrium (5). CGB confers biological specificity, whereas the alpha subunit of HCG is common to all glycoprotein hormones (1).
1. The UniProt Consortium. The Universal Protein Resource (UniProt). Nucleic Acids Res. 36:D190-D195 (2009). 2. Godine et al. J. Biol. Chem. 257:8368-71,1982. 3. Cole LA. Expert Rev Mol Diagn. 9(7):721-47, 2009. 4. Handschuh K et al. Placenta. 30(12):1016-22, 2009. 5. Stenman UH et al. Hum Reprod Update. 12(6):769-84, 2006.
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