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>   home   >   Products   >   Primary Antibodies   >   Cancer   >   c-Myb Antibody   

c-Myb Antibody

Rabbit Monoclonal Antibody

  • WB - c-Myb Antibody AJ1192a
    A. Western blot analysis on Ramos membrane using anti-c-Myb RabMAb (Cat. #AJ1192a), dilution 1:10,000
  • IHC - c-Myb Antibody AJ1192a
    B. Immunohistochemical staining of paraffin-embedded human cervical carcinoma using anti-c-Myb RabMAb (Cat. #AJ1192a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P10242
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP769Y
Calculated MW 72341 Da
Gene ID 4602
Other Names Transcriptional activator Myb, Proto-oncogene c-Myb, MYB
Target/Specificity A synthetic peptide corresponding to residues near the N-terminus of human c-myb was used as an immunogen.
Dilution WB~~1:10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautionsc-Myb Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MYB
Function Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00625, ECO:0000269|PubMed:19646965}
Research Areas
Citations (0)

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The c-Myb proto-oncogene is a 75 kDa protein involved in growth regulation and differentiation in many different cell types but it is predominantly expressed in immature hematopoietic cells where it plays an important role in cell proliferation. c-Myb activity is directly regulated by cyclin D1 and CDKs and it is believed that c-Myb activity is regulated during the cell cycle in hematopoietic cells (2). Disrupting c-myb function might, therefore, prove an effective therapeutic strategy for controlling leukemic cell growth (3). c-Myb binds to promoter sequences of genes such as c-Myc or Bcl-2 that are expressed in cutaneous T-cell lymphoma.


1. Kalkbrenner F, et al. Oncogene(5):657-61, 1990
2. Lei W, et al. Blood(10):3855-61, 2005
3. Ratajczak MZ, et al Proc Natl Acad Sci(24):11823-7, 1992

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Cat# AJ1192a
(40 western blots)
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