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COPS3 Antibody

Rabbit Monoclonal Antibody

  • WB - COPS3 Antibody AJ1193a
    A. Western blot analysis on (A) HT-29, (B) HeLa, (C) SKBR-3 and (D) 293T cell lysates using anti-COPS3 RabMAb (Cat. #AJ1193a), dilution: 1:20,000.
  • IF - COPS3 Antibody AJ1193a
    B. Immunofluorescent staining of HeLa cells using anti-COPS3 RabMAb (Cat. #AJ1193a)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UNS2
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EPR3127
Calculated MW 47873 Da
Gene ID 8533
Other Names COP9 signalosome complex subunit 3, SGN3, Signalosome subunit 3, JAB1-containing signalosome subunit 3, COPS3, CSN3
Target/Specificity A synthetic peptide corresponding to residues at the C-terminus of human COPS3 was used as an immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCOPS3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name COPS3
Synonyms CSN3
Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Cellular Location Cytoplasm. Nucleus
Tissue Location Widely expressed. Expressed at high level in heart and skeletal muscle.
Research Areas
Citations (0)

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COPS3 is a component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. Individual subunits of the complex have been linked to various signal transduction pathways leading to gene expression and cell cycle control (1, 2). Subunit 3 (COPS3) possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-B alpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation (3). COPS3 is suggested as a specific negative regulator of TNF-induced NF-kappaB activation pathways because its over-expression inhibits NF-kappaB activation (4).


1. Tsuge T, et al. J Mol Biol. 305(1):1-9, 2001
2. Fang L., et al. J. Proteome Res. 7:4914-4925, 2008
3. The UniProt Consortium, The Universal Protein Resource (UniProt), Nucleic Acids Res. 36:D190-D195, 2008
4. Hong X, et al. FEBS Lett. 499(1-2):133-6, 2001

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Cat# AJ1193a
(40 western blots)
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